ProRule PRU01400
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01400 |
| Accession | PRU01400 |
| Dates | 3-JAN-2025 (Created)
6-JAN-2025 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52055; UBL_BIL |
Name | Bacterial ISG15-like (Bil) ubiquitin-like domain |
| Function | One antiphage defense system in bacteria, comprises a ubiquitin-like protein, ubiquitin-conjugating enzymes E1 and E2, and a deubiquitinase. Owing to its double-UBL domain and role in antiviral defense, the system was coined "Bil" (bacterial ISG15-like), and is composed of BilA/B/C/D encoding UBL, E2, DUB, and E1 modules, respectively. |
| Scope(s) |
Bacteria Collimonas |
| Example(s) | A0A1I1P2K9 (BILA_COLS4); |
Propagated annotation
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Keywords
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| Antiviral defense | |
| case <FTTag:Ubiquitination> | |
| Isopeptide bond | |
| Ubl conjugation pathway | |
| end case | |
Features
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| From: PS52055 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Ubiquitin-like BIL-type #" | |||||||||
| CROSSLNK | 78 | 78 | /note="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in central tail fiber acceptor protein)" | Ubiquitination | G | |||||||
Additional information
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| Size range | 77-83 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [1] All [ 1 ]
- Retrieve set of proteins with 3D structure for this domain