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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01403


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01403
General rule information [?]

Accession PRU01403
Dates 25-FEB-2025 (Created)
25-FEB-2025 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52058; ZF_UVSSA
Name Zinc finger UVSSA-type
Function The UVSSA-type zinc (Zn)-finger docks on the Pol II jaw: both knuckles of the finger insert their residues into a shallow groove formed by helix 1, consecutive beta-strand and helix 3 of the jaw domain.
Scope(s) Eukaryota
Example(s) Q2YD98;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONChromosome. Note=Accumulates at UV DNA damage sites.
SIMILARITYBelongs to the UVSSA family.

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger
Chromosome
DNA damage
DNA repair

Gene Ontology [?]

GO:0009411; Biological process:response to UV
GO:0005694; Cellular component:chromosome
GO:0000993; Molecular function:RNA polymerase II complex binding
GO:0006283; Biological process:transcription-coupled nucleotide-excision repair
case (<Feature:PS52058:4=[CH]> and <Feature:PS52058:14=[CH]> and <Feature:PS52058:22=[CH]> and <Feature:PS52058:25=[CH]>)
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS52058
Key From To Description Tag Condition FTGroup
case (<Feature:PS52058:4=[C]> and <Feature:PS52058:14=[C]> and <Feature:PS52058:22=[C]> and <Feature:PS52058:25=[H]>)
ZN_FING from to /note="UVSSA-type #"
else case (<Feature:PS52058:4=[CH]> and <Feature:PS52058:14=[CH]> and <Feature:PS52058:22=[CH]> and <Feature:PS52058:25=[CH]>)
ZN_FING from to /note="UVSSA-type #; atypical"
else
ZN_FING from to /note="UVSSA-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 14 14 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 22 22 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 25 25 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 28-28 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]