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ProRule PRU01403


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PURL: https://purl.expasy.org/prosite/rule/PRU01403
General rule information [?]

Accession PRU01403
Dates 25-FEB-2025 (Created)
25-FEB-2025 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52058; ZF_UVSSA
Name Zinc finger UVSSA-type
Function The UVSSA-type zinc (Zn)-finger docks on the Pol II jaw: both knuckles of the finger insert their residues into a shallow groove formed by helix 1, consecutive beta-strand and helix 3 of the jaw domain.
Scope(s) Eukaryota
Example(s) Q2YD98 (UVSSA_HUMAN);

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONChromosome. Note=Accumulates at UV DNA damage sites.
SIMILARITYBelongs to the UVSSA family.

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger
Chromosome
DNA damage
DNA repair

Gene Ontology [?]

GO:0009411; Biological process:response to UV
GO:0005694; Cellular component:chromosome
GO:0000993; Molecular function:RNA polymerase II complex binding
GO:0006283; Biological process:transcription-coupled nucleotide-excision repair
case (<Feature:PS52058:4=[CH]> and <Feature:PS52058:14=[CH]> and <Feature:PS52058:22=[CH]> and <Feature:PS52058:25=[CH]>)
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS52058
Key From To Description Tag Condition FTGroup
case (<Feature:PS52058:4=[C]> and <Feature:PS52058:14=[C]> and <Feature:PS52058:22=[C]> and <Feature:PS52058:25=[H]>)
ZN_FING from to /note="UVSSA-type #"
else case (<Feature:PS52058:4=[CH]> and <Feature:PS52058:14=[CH]> and <Feature:PS52058:22=[CH]> and <Feature:PS52058:25=[CH]>)
ZN_FING from to /note="UVSSA-type #; atypical"
else
ZN_FING from to /note="UVSSA-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 14 14 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 22 22 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 25 25 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 28-28 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]