We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01411
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01411
General rule information
[?]
| Accession | PRU01411 |
| Dates | 04-JUN-2025 (Created)
04-JUN-2025 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52065; MCM10_ID |
Name | MCM10 internal domain (MCM10-ID) |
| Function | The MCM10-ID domain is composed of an oligonucleotide/ oligosaccharide binding (OB)-fold followed in tandem by a variant and highly basic C3H-type zinc finger, which form a unified DNA binding platform. |
| Scope(s) |
Eukaryota |
| Example(s) | Q5RHY1; |
Propagated annotation
[?]
Comments
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| SIMILARITY | Belongs to the MCM10 family. |
Keywords
[?]
| Metal-binding | |
| Zinc | |
| Zinc-finger | |
| end case | |
| DNA replication | |
| Nucleus | |
Gene Ontology
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| GO:0003697; Molecular function:single-stranded DNA binding | |
| GO:0006270; Biological process:DNA replication initiation | |
| GO:0005634; Cellular component:nucleus | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
Features
[?]
| From: PS52065 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="MCM10-ID #" | |||||||||
| REGION | from | 148 | /note="OB-fold #" | |||||||||
| case <Feature:PS52065:153=[C]> and <Feature:PS52065:163=[C]> and <Feature:PS52065:175=[C]> and <Feature:PS52065:178=[H]> | ||||||||||||
| REGION | 149 | 191 | /note="CCCH-type zinc finger (ZnF1) #" | |||||||||
| else case <FTGroup:1> | ||||||||||||
| REGION | 149 | 191 | /note="CCCH-type zinc finger (ZnF1) #; atypical" | |||||||||
| else | ||||||||||||
| REGION | 149 | 191 | /note="CCCH-type zinc finger (ZnF1) #; degenerate" | |||||||||
| end case | ||||||||||||
| MOTIF | 89 | 95 | /note="PCNA-interacting peptide (PIP) box" | |||||||||
| MOTIF | 110 | 117 | /note="Hsp10-like" | |||||||||
| BINDING | 153 | 153 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 163 | 163 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 175 | 175 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 178 | 178 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
Additional information
[?]
| Size range | 192-203 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.