ProRule PRU01411
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01411
General rule information
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| Accession | PRU01411 |
| Dates | 04-JUN-2025 (Created)
04-JUN-2025 (Last updated, Version ) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52065; MCM10_ID |
Name | MCM10 internal domain (MCM10-ID) |
| Function | The MCM10-ID domain is composed of an oligonucleotide/ oligosaccharide binding (OB)-fold followed in tandem by a variant and highly basic C3H-type zinc finger, which form a unified DNA binding platform. |
| Scope(s) |
Eukaryota |
| Example(s) | Q5RHY1; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the MCM10 family. |
Keywords
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| Metal-binding | |
| Zinc | |
| Zinc-finger | |
| end case | |
| DNA replication | |
| Nucleus | |
Gene Ontology
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| GO:0003697; Molecular function:single-stranded DNA binding | |
| GO:0006270; Biological process:DNA replication initiation | |
| GO:0005634; Cellular component:nucleus | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
Features
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| From: PS52065 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="MCM10-ID #" | |||||||||
| REGION | from | 148 | /note="OB-fold #" | |||||||||
| case <Feature:PS52065:153=[C]> and <Feature:PS52065:163=[C]> and <Feature:PS52065:175=[C]> and <Feature:PS52065:178=[H]> | ||||||||||||
| REGION | 149 | 191 | /note="CCCH-type zinc finger (ZnF1) #" | |||||||||
| else case <FTGroup:1> | ||||||||||||
| REGION | 149 | 191 | /note="CCCH-type zinc finger (ZnF1) #; atypical" | |||||||||
| else | ||||||||||||
| REGION | 149 | 191 | /note="CCCH-type zinc finger (ZnF1) #; degenerate" | |||||||||
| end case | ||||||||||||
| MOTIF | 89 | 95 | /note="PCNA-interacting peptide (PIP) box" | |||||||||
| MOTIF | 110 | 117 | /note="Hsp10-like" | |||||||||
| BINDING | 153 | 153 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 163 | 163 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 175 | 175 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 178 | 178 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
Additional information
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| Size range | 192-203 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [8] All [ 8 ]
- Retrieve set of proteins with 3D structure for this domain