ProRule PRU01450
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PURL: https://purl.expasy.org/prosite/rule/PRU01450
General rule information
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| Accession | PRU01450 |
| Dates | 21-MAY-2026 (Created)
21-MAY-2026 (Last updated, Version ) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52106; HV_L_CBD |
Name | Hantaviridae family large (L) protein cap-binding domain (CBD) |
| Function | The endonuclease and cap-binding functions are required for viral transcription initiation via cap-snatching to provide short, capped RNA primers derived from host cell mRNAs. |
| Scope(s) |
Viruses Orthohantavirus |
| Example(s) | Q9YQR5 (L_TULV); |
Propagated annotation
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Comments
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| DOMAIN | The C-terminus contains the cap-binding region. |
| SIMILARITY | Belongs to the Bunyavirales RNA polymerase family. |
Keywords
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Gene Ontology
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| GO:0006351; Biological process:DNA-templated transcription |
| GO:0075526; Biological process:cap snatching |
Features
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| From: PS52106 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Cap-binding Hantaviridae-type #" | |||||||||
Additional information
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| Size range | 119-119 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [9] All [ 9 ]
- Retrieve set of proteins with 3D structure for this domain