We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU10018
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU10018
General rule information
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| Accession | PRU10018 |
| Dates | 16-OCT-2006 (Created)
03-SEP-2024 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS00094; C5_MTASE_1 |
Name | C-5 cytosine-specific DNA methylases active site |
| Function | Undefined |
| Scope(s) |
Eukaryota Bacteria Archaea Viruses |
| Example(s) | P25262; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=DNA (cytosine-5-)-methyltransferase; EC=2.1.1.37; |
Comments
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| CATALYTIC ACTIVITY | Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5- methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37; |
Features
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| From: PS00094 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 5 | 5 | ||||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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