ProRule PRU10030

General rule information [?]

Accession PRU10030
Dates 16-OCT-2006 (Created)
20-DEC-2023 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS00469; NDPK
Name Nucleoside diphosphate kinase (NDPK) active site
Function There is a single histidine residue involved in the catalytic mechanism, conserved in all known active NDPK enzymes.
Scope(s) Eukaryota
Example(s) P81766 (NDK3_SPIOL);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=Nucleoside-diphosphate kinase;

Comments [?]

CATALYTIC ACTIVITY Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=;
CATALYTIC ACTIVITY Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=;

Features [?]

From: PS00469
Key From To Description Tag Condition FTGroup
ACT_SITE 2 2 /note="Pros-phosphohistidine intermediate"

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]