ProRule PRU10030
General rule information
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| Accession | PRU10030 |
| Dates | 16-OCT-2006 (Created)
20-DEC-2023 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS00469; NDPK |
Name | Nucleoside diphosphate kinase (NDPK) active site |
| Function | There is a single histidine residue involved in the catalytic mechanism, conserved in all known active NDPK enzymes. |
| Scope(s) |
Eukaryota Bacteria Archaea Viruses |
| Example(s) | P81766 (NDK3_SPIOL); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=Nucleoside-diphosphate kinase; EC=2.7.4.6; |
Comments
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| CATALYTIC ACTIVITY | Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; |
| CATALYTIC ACTIVITY | Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; |
Features
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| From: PS00469 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 2 | 2 | /note="Pros-phosphohistidine intermediate" | |||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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