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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU10086


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU10086
General rule information [?]

Accession PRU10086
Dates 16-OCT-2006 (Created)
28-APR-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS00382; CLP_PROTEASE_HIS
Name Endopeptidase Clp histidine active site
Function Undefined
Scope(s) Eukaryota
Bacteria
Example(s) Q81PL4;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=Endopeptidase Clp;
                 EC=3.4.21.92;

Comments [?]

CATALYTIC ACTIVITY Reaction=Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr- Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).; EC=3.4.21.92;

Features [?]

From: PS00382
Key From To Description Tag Condition FTGroup
ACT_SITE 6 6

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]