ProRule PRU10094
General rule information
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| Accession | PRU10094 |
| Dates | 16-OCT-2006 (Created)
22-NOV-2019 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS00141; ASP_PROTEASE |
Name | Eukaryotic and viral aspartyl proteases active site |
| Function | Undefined |
| Scope(s) |
Eukaryota Viruses |
| Example(s) | P56817 (BACE1_HUMAN); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=Pepsin A; EC=3.4.23.1; |
Comments
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| CATALYTIC ACTIVITY | Reaction=Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His- 5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu- 17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.; EC=3.4.23.1; |
Features
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| From: PS00141 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 4 | 4 | ||||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [398] Viruses [151] All [ 549 ]
- Retrieve set of proteins with 3D structure for this domain