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| annotation rule: PRU10094 |
General rule information
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| Accession | PRU10094 |
| Dates | 16-OCT-2006 (Created) 27-OCT-2018 (Last updated, Version 4) |
| Data class | Domain |
| Predictors | PROSITE; PS00141; ASP_PROTEASE |
| Name | Eukaryotic and viral aspartyl proteases active site |
| Function | Undefined. |
Propagated annotation
[?]
Description
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| + AltName: Full=Pepsin A; EC=3.4.23.1; |
Comments
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| Catalytic activity | Reaction=Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4- Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|- Tyr-26 bonds in the B chain of insulin.; EC=3.4.23.1;. |
Features
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| From: PS00141 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 4 | 4 | ||||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P56817 (BACE1_HUMAN) |
| Scope | Eukaryota
Viruses |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [365] Viruses [150] All [ 515 ]
- Retrieve set of proteins with 3D structure for this domain