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annotation rule: PRU10094 |
Accession | PRU10094 |
Dates | 16-OCT-2006 (Created) 22-NOV-2019 (Last updated, Version 5) |
Data class | Domain |
Predictors | PROSITE; PS00141; ASP_PROTEASE |
Name | Eukaryotic and viral aspartyl proteases active site |
Function | Undefined. |
+ AltName: Full=Pepsin A; EC 3.4.23.1; |
Catalytic activity | Reaction=Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.; EC=3.4.23.1; |
From: PS00141 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 4 | 4 |
Size range | unlimited amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | P56817 (BACE1_HUMAN) |
Scope | Eukaryota
Viruses |
Eukaryota | [395] | |
Viruses | [150] | |
All | [ 545 ] |