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annotation rule: PRU10094

General rule information [?]

Accession PRU10094
Dates 16-OCT-2006 (Created)
27-OCT-2018 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS00141; ASP_PROTEASE
Name Eukaryotic and viral aspartyl proteases active site
Function Undefined.

Propagated annotation [?]


Description [?]

+ AltName: Full=Pepsin A; EC=3.4.23.1;

Comments [?]

Catalytic activity Reaction=Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.; EC=3.4.23.1;.

Features [?]

From: PS00141
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     4     4                

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example P56817 (BACE1_HUMAN)
Scope
Eukaryota
Viruses

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]