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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU10140


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU10140
General rule information [?]

Accession PRU10140
Dates 29-OCT-2018 (Created)
22-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS60032; GH9_1
Name Glycosyl hydrolases family 9 (GH9) active site D
Function Three conserved regions in these enzymes are centered on conserved residues which have been shown to be important for the catalytic activity. The first region contains the characteristic DAGD motif, where the C-terminal D acts as the catalytic base that extracts a proton from the nucleophilic water.
Scope(s) Eukaryota
Bacteria
Example(s) O81416;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=3.2.1.-;

Comments [?]

SIMILARITYBelongs to the glycosyl hydrolase 9 (cellulase E) family.

Keywords [?]

Carbohydrate metabolism
Glycosidase
Hydrolase
Polysaccharide degradation

Gene Ontology [?]

GO:0004553; Molecular function:hydrolase activity, hydrolyzing O-glycosyl compounds

Features [?]

From: PS60032
Key From To Description Tag Condition FTGroup
ACT_SITE 9 9 /note="Nucleophile" D

Additional information [?]

Size range 18-18 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]