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ProRule PRU01108


General rule information [?]

Accession PRU01108
Dates 25-AUG-2015 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51772; ACD
Name Actin cross-linking (ACD) domain
Function ACDs are enzyme ligases that catalyze the formation of an irreversible iso-peptide bond on two actin molecules in an ATP- and Mg/ Mn(2+)-dependent manner.
Scope(s) Bacteria
Vibrio
Example(s) A0A0H3AIG7 (VGRG1_VIBC3);

Propagated annotation [?]

Keywords [?]

case <FTGroup:1>
ATP-binding
Nucleotide-binding
end case
case <FTGroup:2>
Magnesium
Metal-binding
end case
case <FTGroup:1> and <FTGroup:2>
Ligase
end case

Features [?]

From: PS51772
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ACD #"
BINDING 12 16 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 S-I-G-[IT]-E 1
BINDING 16 16 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
/ligand_note="catalytic; for actin cross-linking activity"		 E 2
BINDING 16 16 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
/ligand_note="catalytic; for actin cross-linking activity"		 E 2
BINDING 78 78 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
/ligand_note="catalytic; for actin cross-linking activity"		 E 2
BINDING 162 162 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
/ligand_note="catalytic; for actin cross-linking activity"		 Q 2
BINDING 339 339 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
/ligand_note="catalytic; for actin cross-linking activity"		 E 2
BINDING 81 81 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 [ST] 1
BINDING 268 268 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 R 1

Additional information [?]

Size range 425-446 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]