ProRule PRU01266
General rule information
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| Accession | PRU01266 |
| Dates | 20-MAR-2020 (Created)
19-NOV-2022 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51918; RADICAL_SAM |
Name | Radical SAM core domain |
| Function | The radical SAM enzymes biochemically characterized to date have in common the cleavage of the [4Fe-4S]1+-SAM complex to [4Fe-4S]2+-Met and the 5'-deoxyadenosyl radical, which abstracts a hydrogen atom from the substrate to initiate a radical mechanism. |
| Scope(s) |
Bacteria Eukaryota Archaea Viruses |
| Example(s) | Q5YT08 (MIAB_NOCFA); |
Propagated annotation
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Comments
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| case <FTGroup:1> | |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; |
Keywords
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Gene Ontology
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| GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding |
| GO:0046872; Molecular function:metal ion binding |
Features
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| From: PS51918 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Radical SAM core #" | |||||||||
| BINDING | 15 | 15 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet" |
C | 1 | |||||||
| BINDING | 19 | 19 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet" |
C | 1 | |||||||
| BINDING | 22 | 22 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet" |
C | 1 | |||||||
Additional information
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| Size range | 200-300 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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