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PROSITE entry PS00135


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00135
Entry name [info] TRYPSIN_SER
Accession [info] PS00135
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1995 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00124
Associated ProRule [info] PRU10079

Name and characterization of the entry

Description [info] Serine proteases, trypsin family, serine active site.
Pattern [info] 
[DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-[LIVMFYWH]-
[LIVMFYSTANQH].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 682 in 678 different sequences
Number of true positive hits 664 in 660 different sequences
Number of 'unknown' hits 0
Number of false positive hits 18 in 18 different sequences
Number of false negative sequences 105
Number of 'partial' sequences 77
Precision (true positives / (true positives + false positives)) 97.36 %
Recall (true positives / (true positives + false negatives)) 86.35 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Site [info] active_site at position 6
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 660 sequences 

ACH1_LONAC  (P23604), ACH2_LONAC  (P23605), ACRO_HUMAN  (P10323),
ยป more

UniProtKB/Swiss-Prot
False negative sequences		 105 sequences 

APOA_MACMU  (P14417), CAP7_HUMAN  (P20160), CAP7_PIG(P80015),
ยป more

UniProtKB/Swiss-Prot
'Partial' sequences		 77 sequences 

ACRO_CAPHI  (P10626), CBP_OLIMR   (P0C8M2), CFAB_PIG(Q03710),
ยป more

UniProtKB/Swiss-Prot
False positive sequences		 18 sequences 

CTSZ_SPOGL  (Q8RQU9), EMAL4_HUMAN (Q9HC35), EMAL4_MOUSE (Q3UMY5),
ยป more

PDB
[Detailed view]		 2270 PDB

1A0H; 1A0J; 1A0L; 1A2C; 1A3B; 1A3E; 1A46; 1A4W; 1A5G; 1A5H; 1A5I; 1A61;
ยป more