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Database of protein domains, families and functional sites

PROSITE consists of documentation entries describing protein domains, families and functional sites as well as associated patterns and profiles to identify them [More... / References / Commercial users].
PROSITE is complemented by ProRule, a collection of rules based on profiles and patterns, which increases the discriminatory power of profiles and patterns by providing additional information about functionally and/or structurally critical amino acids [More...].

Forthcoming changes to the profile format

Release 20.106 of 03-Sep-2014 contains 1704 documentation entries, 1308 patterns, 1089 profiles and 1077 ProRule.

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e.g. PDOC00022, PS50089, SH3, zinc finger



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Quick Scan mode of ScanProsite
Quickly find matches of your protein sequences to PROSITE signatures (max. 10 sequences). [?] Examples


Exclude motifs with a high probability of occurrence from the scan

For more scanning options go to ScanProsite
Other tools
  • PRATT -  allows to interactively generate conserved patterns from a series of unaligned proteins.
  • MyDomains - Image Creator -  allows to generate custom domain figures.
scanview