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| Entry: PS50006 |
General information about the entry
| Entry name [info] | FHA_DOMAIN |
| Accession [info] | PS50006 |
| Entry type [info] | MATRIX |
| Date [info] | NOV-1995 (CREATED); OCT-2013 (DATA UPDATE); JUN-2016 (INFO UPDATE). |
| PROSITE Doc. [info] | PDOC50006 |
| Associated ProRule [info] | PRU00086 |
Name and characterization of the entry
| Description [info] | Forkhead-associated (FHA) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=53; TOPOLOGY=LINEAR; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=48; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.8473000; R2=0.0187000; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2669.5043945; R2=1.9115044; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=1; SCORE=410; H_SCORE=3451; N_SCORE=8.5; MODE=1; TEXT='!!'; /CUT_OFF: LEVEL=0; SCORE=330; H_SCORE=3300; N_SCORE=7.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=276; H_SCORE=3197; N_SCORE=6.0; MODE=1; TEXT='?'; /DEFAULT: B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; I=-20; D=-20; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='V'; M= -6,-26,-15,-30,-25, 5,-29,-24, 16,-19, 7, 5,-24,-26,-22,-19,-16, -6, 18, -6, 3,-24; /M: SY='T'; M= -8,-12,-22,-16,-11, -6,-19,-10, -6, -2, -7, -3, -6,-18, -8, 3, -2, 5, -2,-21, -3,-11; /M: SY='I'; M=-10,-29,-24,-35,-27, 16,-30,-25, 28,-29, 22, 13,-22,-25,-25,-24,-20,-10, 19,-15, 3,-27; /M: SY='G'; M= 0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20, 0,-20,-20,-20, 0,-20,-30,-20,-30,-20; /M: SY='R'; M=-19, -8,-30, -8, 1,-21,-20, 5,-30, 29,-21, -9, 1,-19, 10, 62,-10,-11,-21,-21, -8, 1; /M: SY='N'; M= -6, 4,-23, -2, -6,-16, -7, 1,-15, -3,-21,-12, 15,-10, -3, 2, 4, -3,-16,-27, -9, -7; /M: SY='S'; M= 3, -1,-18, -4, -2,-18,-14,-14,-12, -3,-17,-12, 1, -8, -4, -5, 11, 11, -5,-30,-15, -4; /M: SY='D'; M= -6, 16,-25, 24, 17,-29,-12, -7,-28, 3,-26,-21, 6, 1, 2, -6, 7, 1,-22,-34,-19, 9; /I: MI=-12; MD=-12; IM=-12; I=-4; /M: SY='R'; D=-2; M= -6, 1,-17, 0, 3,-16, -5, -2,-14, 4,-13, -8, 6, -6, 6, 7, 1, -4,-15,-19,-11, 4; /I: DM=-12; /M: SY='C'; M= -4,-20, 45,-25,-23,-14,-22,-26, -9,-22,-10, -9,-18,-26,-23,-21, -6, -5, 5,-38,-21,-24; /M: SY='D'; M=-18, 42,-29, 56, 20,-38,-10, 2,-36, 1,-29,-26, 21,-11, 7, -7, 1, -9,-30,-38,-19, 13; /M: SY='V'; M= -5,-27,-10,-29,-25, -1,-26,-23, 20,-22, 15, 10,-25,-28,-21,-20,-15, -6, 25,-24, -5,-24; /M: SY='A'; M= 2, -3,-19, -6, -7,-12,-14, -6,-10, -4,-11, -8, 0,-17, -7, -3, 2, 0, -5,-25, -7, -8; /I: MD=-10; /M: SY='L'; D=-3; M= -2,-11,-13,-11, -6, -3, -9, -5, 1,-12, 11, 6,-10,-14, -6, -9, -7, -4, -1,-15, -4, -6; /I: MI=0; IM=0; DM=-10; I=-5; /M: SY='L'; M= -6,-21,-17,-25,-20, 3, -2,-19, -2,-23, 7, 4,-16,-24,-17,-19,-14,-12, -4,-17, -6,-19; /M: SY='E'; M=-10, 9,-28, 12, 16,-27,-11, -5,-25, 6,-22,-16, 7, 1, 5, 0, 0, -5,-24,-30,-18, 10; /M: SY='S'; M= 0, 5,-22, 6, 0,-23, -2, -5,-20,-10,-21,-16, 7, -3, -4,-12, 10, -1,-17,-33,-18, -3; /M: SY='P'; M= -8, -5,-29, -4, 4,-26,-11, -9,-23, 10,-26,-12, -2, 15, 3, 5, -1, -6,-22,-27,-19, 2; /M: SY='V'; M= -8,-11,-19,-12,-12, 1,-21,-15, 0,-10, -3, -3, -8,-22,-14, -4, -4, -3, 6,-24, -6,-13; /M: SY='I'; M= -7,-30,-22,-35,-28, 2,-35,-28, 38,-27, 22, 17,-25,-25,-23,-25,-19, -7, 33,-23, -3,-28; /M: SY='S'; M= 10, 0,-10, 0, 0,-20, 0,-10,-20,-10,-30,-20, 10,-10, 0,-10, 40, 20,-10,-40,-20, 0; /M: SY='R'; M=-14, -4,-27, -6, -2,-21, -8, -3,-29, 20,-22,-12, 6,-19, 5, 46, -4, -6,-21,-23,-13, -2; /M: SY='R'; M=-10, -9,-15,-14,-11, -6,-22,-10, -5, 2, -9, -2, -4,-22, -7, 4, -8, -4, 1,-22, -4,-10; /M: SY='H'; M=-20, 0,-30, 0, 0,-20,-20,100,-30,-10,-20, 0, 10,-20, 10, 0,-10,-20,-30,-30, 20, 0; /M: SY='A'; M= 23,-15, 21,-24,-18,-10, -9,-23,-14,-18, -9,-11,-14,-21,-19,-23, 0, -5, -3,-25,-18,-18; /M: SY='Q'; M= -6, -7,-14, -8, 4,-17,-21, -9,-12, -2,-10, -6, -7,-16, 7, 0, -5, -7,-10,-24,-11, 5; /M: SY='I'; M=-10,-30,-23,-36,-28, 13,-35,-26, 33,-29, 25, 16,-24,-25,-24,-25,-21, -9, 24,-17, 3,-28; /M: SY='Y'; M=-11,-10,-23,-13, -5, 3,-20, 5,-16, -5,-11, -7, -5,-18, -4, 0, -3, -1,-14,-10, 6, -5; /M: SY='Y'; M=-10,-21, -6,-24,-19, 8,-27, -5, -2,-15, 2, 0,-19,-27,-14,-14,-16,-10, -2, -3, 19,-18; /M: SY='D'; M=-10, 11,-26, 12, 6,-24, 0, -1,-23, -3,-18,-14, 9,-15, 0, -6, -2, -7,-21,-30,-16, 3; /I: MD=-10; /M: SY='P'; D=-3; M=-10, -5,-22, -6, -2, -3,-15, -3,-12, -7,-10, -6, -2, 6, -5, -5, -6, -6,-15,-19, -6, -4; /I: MD=-10; /M: SY='Q'; D=-3; M= -8, 0,-16, -2, 0,-10,-10, 2,-12, -2, -7, -3, 1,-11, 4, 1, -2, 0,-11,-16, -4, 2; /I: MI=0; IM=0; DM=-10; I=-5; /M: SY='D'; M= -7, 4,-23, 6, 5,-22, -9,-10,-18, -2,-18,-13, 3,-13, 0, -2, 5, 2,-13,-30,-16, 2; /M: SY='G'; M= -7, -1,-30, -3, -4,-22, 10,-11,-27, -5,-26,-17, 4, 0, -5, -7, -4,-12,-27,-15,-18, -5; /M: SY='R'; M= -4, -2,-24, -5, 4,-20, -8, -2,-20, 7,-16, -8, 2,-15, 1, 10, -2, -6,-15,-25,-13, 1; /M: SY='W'; M=-10,-28,-27,-31,-24, 15,-26,-17, 4,-20, 1, -1,-25,-27,-19,-18,-20,-12, 4, 27, 14,-20; /M: SY='Y'; M=-10,-10,-25,-10, -3, 3,-16, 3,-10, -9, -7, -6, -6,-19, -6, -9, -5, -6,-12,-10, 15, -6; /M: SY='L'; M= -8,-30,-21,-33,-24, 6,-33,-24, 30,-28, 35, 18,-27,-27,-22,-23,-24, -8, 22,-22, -2,-24; /M: SY='H'; M=-11, 1,-27, 2, 11,-19,-19, 14,-21, 5,-18, -9, 3,-14, 8, 8, -4, -9,-19,-26, -6, 8; /M: SY='D'; M=-16, 27,-14, 37, 8,-30,-17, -7,-23, -7,-21,-20, 10,-15, -6,-14, -3, -9,-17,-38,-18, 0; /I: MI=0; IM=0; I=-8; /M: SY='A'; M= -8,-14,-18,-17,-14, -8, -5, -7,-10,-10, -6, -3, -8,-20,-13,-10, -8, -8, -8,-22, -7,-14; /M: SY='S'; M= 7, -3,-16, -3, -6,-23, 20,-13,-26,-13,-30,-20, 7,-13, -6,-13, 29, 9,-16,-34,-23, -6; /M: SY='T'; M= -2, -4,-17, -7, -1,-16,-15,-11,-15, 2,-14, -8, -1,-13, -1, 5, 11, 14, -8,-29,-12, -1; /M: SY='N'; M= -9, 32,-20, 16, 1,-21, -2, 13,-21, -1,-29,-18, 50,-19, 4, 0, 11, 0,-28,-38,-17, 2; /M: SY='G'; M= -1,-12,-29,-11,-20,-28, 59,-21,-35,-19,-28,-18, -3,-15,-20,-20, -1,-18,-25,-21,-29,-20; /M: SY='T'; M= 6, -5, -4,-13,-11,-11,-17,-20, -9,-12, -9, -9, -4,-13,-11,-13, 16, 32, 1,-31,-13,-11; /M: SY='F'; M=-16,-22,-25,-26,-18, 29,-28, -9, -1,-13, 6, 1,-18,-26,-16, -8,-18, -8, -5, 7, 25,-17; /M: SY='V'; M= -5,-29,-17,-32,-26, 3,-31,-25, 30,-24, 25, 18,-28,-28,-23,-21,-19, -5, 32,-25, -5,-26; /M: SY='N'; M=-11, 38,-21, 25, 5,-23, -3, 7,-23, 0,-29,-21, 49,-17, 1, -2, 9, 1,-29,-39,-20, 3; /M: SY='G'; M= -8, 2,-26, 0,-10,-12, 21, -1,-28,-11,-23,-16, 10,-20,-12,-11, -1,-12,-24,-21,-10,-11; /M: SY='Q'; M= -5, -7,-21,-10, -3,-17,-20, -5, -6, -1, -7, -2, -3,-18, 4, 4, -3, -3, -3,-26,-10, 0; /M: SY='R'; M=-15,-14,-27,-14, -5, -8,-22, -8,-18, 15,-11, -6, -7,-16, -1, 36,-11, -8,-11,-19, -7, -6; /M: SY='L'; M= -9,-24,-22,-27,-18, -1,-30,-13, 20,-22, 24, 17,-21,-24,-10,-17,-19, -7, 13,-22, -2,-15; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 153 in 151 different sequences |
| Number of true positive hits | 148 in 146 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 5 in 5 different sequences |
| Number of false negative sequences | 36 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 96.73 % |
| Recall (true positives / (true positives + false negatives)) | 80.43 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | K_Hofmann |
| Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 2 |
| Feature key [info] | DOMAIN |
| Feature description [info] | FHA |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
146 sequences
ABA2_NICPL (Q40412 ), ABA2_PRUAR (O81360 ), ABA2_SOLLC (P93236 ), ABC1_MYCTU (O65934 ), AGGF1_HUMAN (Q8N302 ), AGGF1_MOUSE (Q7TN31 ), C170B_HUMAN (Q9Y4F5 ), C170B_MOUSE (Q80U49 ), C170B_XENLA (Q498L0 ), C170B_XENTR (A0JM08 ), CDS1_SCHPO (Q09170 ), CE170_HUMAN (Q5SW79 ), CE170_MOUSE (Q6A065 ), CHFR_DANRE (A5WW08 ), CHFR_HUMAN (Q96EP1 ), CHFR_MOUSE (Q810L3 ), CHFR_PONAB (Q5RF77 ), CHFR_XENLA (Q5FWP4 ), CHFR_XENTR (Q6P256 ), CHK2_CAEEL (Q9U1Y5 ), CHK2_HUMAN (O96017 ), CHK2_MOUSE (Q9Z265 ), DDL_ARATH (Q8W4D8 ), DMA1_SCHPO (Q10322 ), DMA1_YEAST (P38823 ), DMA2_YEAS7 (A6ZRW7 ), DMA2_YEAST (P53924 ), DUN1_YEAST (P39009 ), EMBR_MYCBO (P66800 ), EMBR_MYCTO (P9WGJ8 ), EMBR_MYCTU (P9WGJ9 ), FAR10_YEAST (Q06001 ), FHA1_ARATH (Q9SFV6 ), FHA1_TOBAC (Q945P0 ), FHA2_ARATH (Q9SFV2 ), FHAA_MYCTU (P71590 ), FHAB_MYCS2 (A0QNG6 ), FHAB_MYCTO (P9WJB4 ), FHAB_MYCTU (P9WJB5 ), FHAD1_HUMAN (B1AJZ9 ), FHAD1_MOUSE (A6PWD2 ), FHKA_DICDI (Q54BF0 ), FHKB_DICDI (Q1ZXH2 ), FHKC_DICDI (P34101 ), FHKD_DICDI (Q54MH0 ), FHKE_DICDI (Q54VI1 ), FHL1_CANAL (Q59ZC8 ), FHL1_SCHPO (O14270 ), FHL1_YEAST (P39521 ), FKH1_YEAST (P40466 ), FKH2_CANAL (Q5A7S7 ), FKH2_SCHPO (O60129 ), FKH2_YEAST (P41813 ), FORJ_DICDI (Q54ER5 ), FOXK1_HUMAN (P85037 ), FOXK1_MOUSE (P42128 ), FOXK2_HUMAN (Q01167 ), FOXK2_MOUSE (Q3UCQ1 ), FOXK2_XENLA (Q7ZX03 ), FRAH_NOSS1 (P46017 ), GARA_MYCS2 (A0QYG2 ), GARA_MYCTO (P9WJA8 ), GARA_MYCTU (P9WJA9 ), KI67_HUMAN (P46013 ), KIF14_MOUSE (L0N7N1 ), KIF1A_HUMAN (Q12756 ), KIF1A_MOUSE (P33173 ), KIF1B_HUMAN (O60333 ), KIF1B_MOUSE (Q60575 ), KIF1B_RAT (O88658 ), LOK_DROME (O61267 ), MCRS1_HUMAN (Q96EZ8 ), MCRS1_MOUSE (Q99L90 ), MDC1_HUMAN (Q14676 ), MDC1_MACMU (Q5TM68 ), MDC1_MOUSE (Q5PSV9 ), MDC1_PANTR (Q7YR40 ), MDC1_PIG (Q767L8 ), MDC1_RAT (Q5U2M8 ), MEK1_SCHPO (Q10292 ), MEK1_YEAST (P24719 ), NADAP_HUMAN (Q9BWU0 ), NBN_CHICK (Q9DE07 ), NBN_DANRE (Q5I2W8 ), NBN_HUMAN (O60934 ), NBN_MOUSE (Q9R207 ), NBN_PONAB (Q5RCV3 ), NBN_RAT (Q9JIL9 ), NBS1_ARATH (Q0H8D7 ), NBS1_ORYSI (B8BHK8 ), NBS1_ORYSJ (Q7XD82 ), NBS1_SCHPO (O43070 ), ODHI_CORDI (Q6NHD4 ), ODHI_COREF (Q8FTJ5 ), ODHI_CORGL (Q8NQJ3 ), ODHI_CORJK (Q4JVU0 ), P2C70_ARATH (P46014 ), PHF12_HUMAN (Q96QT6 ), PHF12_MOUSE (Q5SPL2 ), PLM2_YEAST (Q04383 ), PML1_YEAST (Q07930 ), PP1R8_BOVIN (Q28147 ), PP1R8_HUMAN (Q12972 ), PP1R8_MOUSE (Q8R3G1 ), PS1_ARATH (B7SY83 ), RAD53_YEAST (P22216 ), RNF8A_XENLA (Q7ZX20 ), RNF8B_XENLA (Q6NRG0 ), RNF8_BOVIN (Q2HJ46 ), RNF8_DANRE (Q803C1 ), RNF8_HUMAN (O76064 ), RNF8_MOUSE (Q8VC56 ), RNF8_PONAB (Q5R4I2 ), RNF8_RAT (Q4KLN8 ), SLMAP_HUMAN (Q14BN4 ), SLMAP_MOUSE (Q3URD3 ), SLMAP_RABIT (Q28623 ), SLMAP_RAT (P0C219 ), SNIP1_HUMAN (Q8TAD8 ), SNIP1_MOUSE (Q8BIZ6 ), SNIP1_RAT (Q5M9G6 ), STAR9_MOUSE (Q80TF6 ), TCF19_HUMAN (Q9Y242 ), TCF19_MACMU (Q5TM48 ), TCF19_MOUSE (Q99KJ5 ), TCF19_PANTR (Q7YR48 ), TCF19_PIG (Q9TSV4 ), TIFA_BOVIN (A2VDM0 ), TIFA_HUMAN (Q96CG3 ), TIFA_MOUSE (Q793I8 ), TIFA_RAT (Q5XIB9 ), TIFA_XENLA (Q2MHQ9 ), TIFA_XENTR (B5DE70 ), TOS4_YEAST (Q06266 ), VPS64_YEAST (Q03944 ), Y1858_MYCBO (P64898 ), Y1895_SYNY3 (P74101 ), Y4449_ARATH (O23305 ), Y8013_DICDI (Q54VU4 ), YGI1_YEAST (P53156 ), YK42_SCHPO (Q9P7G6 ), YKI5_CAEEL (P46012 ), YNVD_SCHPO (O74388 ), YOT2_CAEEL (P34648 ), ZEP_ARATH (Q9FGC7 ), ZEP_ORYSJ (Q0JCU7 )» more
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| UniProtKB/Swiss-Prot False negative sequences |
36 sequences
ABA2_CAPAN (Q96375 ), AFAD_HUMAN (P55196 ), AFAD_MOUSE (Q9QZQ1 ), AFAD_RAT (O35889 ), KI13A_HUMAN (Q9H1H9 ), KI13A_MOUSE (Q9EQW7 ), KI13B_HUMAN (Q9NQT8 ), KI16B_HUMAN (Q96L93 ), KI16B_MOUSE (B1AVY7 ), KIF14_HUMAN (Q15058 ), KIF1A_AEDAE (Q17BU3 ), KIF1A_ANOGA (Q7PHR1 ), KIF1A_DROME (A1ZAJ2 ), KIF1A_DROPS (Q28WQ1 ), KIF1C_HUMAN (O43896 ), KIF1C_MOUSE (O35071 ), KIF1C_RAT (O35787 ), KIF1_DICDI (Q9NGQ2 ), KIF28_HUMAN (B7ZC32 ), KIF28_MOUSE (D3YXS5 ), KIF28_RAT (F8WLE0 ), PELI2_HUMAN (Q9HAT8 ), PELI2_MOUSE (Q8BST6 ), PHLB1_HUMAN (Q86UU1 ), PHLB1_MOUSE (Q6PDH0 ), PNKP_HUMAN (Q96T60 ), PNKP_MOUSE (Q9JLV6 ), RADIL_DANRE (A7UA95 ), RADIL_HUMAN (Q96JH8 ), RADIL_MOUSE (Q69Z89 ), STAR9_HUMAN (Q9P2P6 ), TIFAB_HUMAN (Q6ZNK6 ), TIFAB_MOUSE (Q8JZM6 ), TIFAB_RAT (Q5BK67 ), Y7958_DICDI (Q55FT8 ), ZEP_ONCHC (C3VEQ2 )» more |
| UniProtKB/Swiss-Prot False positive sequences |
5 sequences
CHSAD_CHOCO (Q0VZ70 ), SYA_FINM2 (B0S104 ), SYA_RUTMC (A1AXE0 ), SYA_STAHJ (Q4L6W5 ), SYY_RALSO (Q8Y240 )» more |
| PDB [Detailed view] |
66 PDB
1DMZ; 1FHQ; 1FHR; 1G3G; 1G6G; 1GXC; 1J4K; 1J4L; 1J4O; 1J4P; 1J4Q; 1K2M; 1K2N; 1K3J; 1K3N; 1K3Q; 1LGP; 1LGQ; 1MZK; 1QU5; 1R21; 1UHT; 2A0T; 2AFF; 2CSW; 2EH0; 2FEZ; 2FF4; 2JKD; 2JPE; 2JQI; 2JQJ; 2JQL; 2KB3; 2KB4; 2KFU; 2KKL; 2LC1; 2PIE; 3EGA; 3ELS; 3ELV; 3HUE; 3HUF; 3I0M; 3I0N; 3I6U; 3I6W; 3OUN; 3PO8; 3POA; 3UMZ; 3UN0; 3UNM; 3UNN; 3UOT; 3VA1; 3VA4; 3VPY; 4EGX; 4EJQ; 4H87; 4JON; 4QCJ; 4YM4; 4ZGI » more |
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