Entry: PS50006

General information about the entry
Entry name FHA_DOMAIN
Accession number PS50006
Entry type MATRIX
Date NOV-1995 (CREATED); NOV-1995 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC50006
Associated ProRule PRU00086
Name and characterization of the entry
DescriptionForkhead-associated (FHA) domain profile.
Matrix / Profile 
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=53; TOPOLOGY=LINEAR;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=48;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.8473; R2=0.0187; TEXT='-LogE';
/CUT_OFF: LEVEL=1; SCORE=409; N_SCORE=8.5; MODE=1; TEXT='!!';
/CUT_OFF: LEVEL=0; SCORE=329; N_SCORE=7.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=275; N_SCORE=6.0; MODE=1; TEXT='?';
/DEFAULT: B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; I=-20; D=-20;

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='V'; M= -6,-26,-15,-30,-25,  5,-29,-24, 16,-19,  7,  5,-24,-26,-22,-19,-16, -6, 18, -6,  3,-24;
/M: SY='T'; M= -8,-12,-22,-16,-11, -6,-19,-10, -6, -2, -7, -3, -6,-18, -8,  3, -2,  5, -2,-21, -3,-11;
/M: SY='I'; M=-10,-29,-24,-35,-27, 16,-30,-25, 28,-29, 22, 13,-22,-25,-25,-24,-20,-10, 19,-15,  3,-27;
/M: SY='G'; M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='R'; M=-19, -8,-30, -8,  1,-21,-20,  5,-30, 29,-21, -9,  1,-19, 10, 62,-10,-11,-21,-21, -8,  1;
/M: SY='N'; M= -6,  4,-23, -2, -6,-16, -7,  1,-15, -3,-21,-12, 15,-10, -3,  2,  4, -3,-16,-27, -9, -7;
/M: SY='S'; M=  3, -1,-18, -4, -2,-18,-14,-14,-12, -3,-17,-12,  1, -8, -4, -5, 11, 11, -5,-30,-15, -4;
/M: SY='D'; M= -6, 16,-25, 24, 17,-29,-12, -7,-28,  3,-26,-21,  6,  1,  2, -6,  7,  1,-22,-34,-19,  9;
/I:         MI=-12; MD=-12; IM=-12; I=-4;
/M: SY='R'; D=-2; M= -6,  1,-17,  0,  3,-16, -5, -2,-14,  4,-13, -8,  6, -6,  6,  7,  1, -4,-15,-19,-11,  4;
/I:         DM=-12;
/M: SY='C'; M= -4,-20, 45,-25,-23,-14,-22,-26, -9,-22,-10, -9,-18,-26,-23,-21, -6, -5,  5,-38,-21,-24;
/M: SY='D'; M=-18, 42,-29, 56, 20,-38,-10,  2,-36,  1,-29,-26, 21,-11,  7, -7,  1, -9,-30,-38,-19, 13;
/M: SY='V'; M= -5,-27,-10,-29,-25, -1,-26,-23, 20,-22, 15, 10,-25,-28,-21,-20,-15, -6, 25,-24, -5,-24;
/M: SY='A'; M=  2, -3,-19, -6, -7,-12,-14, -6,-10, -4,-11, -8,  0,-17, -7, -3,  2,  0, -5,-25, -7, -8;
/I:         MD=-10;
/M: SY='L'; D=-3; M= -2,-11,-13,-11, -6, -3, -9, -5,  1,-12, 11,  6,-10,-14, -6, -9, -7, -4, -1,-15, -4, -6;
/I:         MI=0; IM=0; DM=-10; I=-5;
/M: SY='L'; M= -6,-21,-17,-25,-20,  3, -2,-19, -2,-23,  7,  4,-16,-24,-17,-19,-14,-12, -4,-17, -6,-19;
/M: SY='E'; M=-10,  9,-28, 12, 16,-27,-11, -5,-25,  6,-22,-16,  7,  1,  5,  0,  0, -5,-24,-30,-18, 10;
/M: SY='S'; M=  0,  5,-22,  6,  0,-23, -2, -5,-20,-10,-21,-16,  7, -3, -4,-12, 10, -1,-17,-33,-18, -3;
/M: SY='P'; M= -8, -5,-29, -4,  4,-26,-11, -9,-23, 10,-26,-12, -2, 15,  3,  5, -1, -6,-22,-27,-19,  2;
/M: SY='V'; M= -8,-11,-19,-12,-12,  1,-21,-15,  0,-10, -3, -3, -8,-22,-14, -4, -4, -3,  6,-24, -6,-13;
/M: SY='I'; M= -7,-30,-22,-35,-28,  2,-35,-28, 38,-27, 22, 17,-25,-25,-23,-25,-19, -7, 33,-23, -3,-28;
/M: SY='S'; M= 10,  0,-10,  0,  0,-20,  0,-10,-20,-10,-30,-20, 10,-10,  0,-10, 40, 20,-10,-40,-20,  0;
/M: SY='R'; M=-14, -4,-27, -6, -2,-21, -8, -3,-29, 20,-22,-12,  6,-19,  5, 46, -4, -6,-21,-23,-13, -2;
/M: SY='R'; M=-10, -9,-15,-14,-11, -6,-22,-10, -5,  2, -9, -2, -4,-22, -7,  4, -8, -4,  1,-22, -4,-10;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='A'; M= 23,-15, 21,-24,-18,-10, -9,-23,-14,-18, -9,-11,-14,-21,-19,-23,  0, -5, -3,-25,-18,-18;
/M: SY='Q'; M= -6, -7,-14, -8,  4,-17,-21, -9,-12, -2,-10, -6, -7,-16,  7,  0, -5, -7,-10,-24,-11,  5;
/M: SY='I'; M=-10,-30,-23,-36,-28, 13,-35,-26, 33,-29, 25, 16,-24,-25,-24,-25,-21, -9, 24,-17,  3,-28;
/M: SY='Y'; M=-11,-10,-23,-13, -5,  3,-20,  5,-16, -5,-11, -7, -5,-18, -4,  0, -3, -1,-14,-10,  6, -5;
/M: SY='Y'; M=-10,-21, -6,-24,-19,  8,-27, -5, -2,-15,  2,  0,-19,-27,-14,-14,-16,-10, -2, -3, 19,-18;
/M: SY='D'; M=-10, 11,-26, 12,  6,-24,  0, -1,-23, -3,-18,-14,  9,-15,  0, -6, -2, -7,-21,-30,-16,  3;
/I:         MD=-10;
/M: SY='P'; D=-3; M=-10, -5,-22, -6, -2, -3,-15, -3,-12, -7,-10, -6, -2,  6, -5, -5, -6, -6,-15,-19, -6, -4;
/I:         MD=-10;
/M: SY='Q'; D=-3; M= -8,  0,-16, -2,  0,-10,-10,  2,-12, -2, -7, -3,  1,-11,  4,  1, -2,  0,-11,-16, -4,  2;
/I:         MI=0; IM=0; DM=-10; I=-5;
/M: SY='D'; M= -7,  4,-23,  6,  5,-22, -9,-10,-18, -2,-18,-13,  3,-13,  0, -2,  5,  2,-13,-30,-16,  2;
/M: SY='G'; M= -7, -1,-30, -3, -4,-22, 10,-11,-27, -5,-26,-17,  4,  0, -5, -7, -4,-12,-27,-15,-18, -5;
/M: SY='R'; M= -4, -2,-24, -5,  4,-20, -8, -2,-20,  7,-16, -8,  2,-15,  1, 10, -2, -6,-15,-25,-13,  1;
/M: SY='W'; M=-10,-28,-27,-31,-24, 15,-26,-17,  4,-20,  1, -1,-25,-27,-19,-18,-20,-12,  4, 27, 14,-20;
/M: SY='Y'; M=-10,-10,-25,-10, -3,  3,-16,  3,-10, -9, -7, -6, -6,-19, -6, -9, -5, -6,-12,-10, 15, -6;
/M: SY='L'; M= -8,-30,-21,-33,-24,  6,-33,-24, 30,-28, 35, 18,-27,-27,-22,-23,-24, -8, 22,-22, -2,-24;
/M: SY='H'; M=-11,  1,-27,  2, 11,-19,-19, 14,-21,  5,-18, -9,  3,-14,  8,  8, -4, -9,-19,-26, -6,  8;
/M: SY='D'; M=-16, 27,-14, 37,  8,-30,-17, -7,-23, -7,-21,-20, 10,-15, -6,-14, -3, -9,-17,-38,-18,  0;
/I:         MI=0; IM=0; I=-8;
/M: SY='A'; M= -8,-14,-18,-17,-14, -8, -5, -7,-10,-10, -6, -3, -8,-20,-13,-10, -8, -8, -8,-22, -7,-14;
/M: SY='S'; M=  7, -3,-16, -3, -6,-23, 20,-13,-26,-13,-30,-20,  7,-13, -6,-13, 29,  9,-16,-34,-23, -6;
/M: SY='T'; M= -2, -4,-17, -7, -1,-16,-15,-11,-15,  2,-14, -8, -1,-13, -1,  5, 11, 14, -8,-29,-12, -1;
/M: SY='N'; M= -9, 32,-20, 16,  1,-21, -2, 13,-21, -1,-29,-18, 50,-19,  4,  0, 11,  0,-28,-38,-17,  2;
/M: SY='G'; M= -1,-12,-29,-11,-20,-28, 59,-21,-35,-19,-28,-18, -3,-15,-20,-20, -1,-18,-25,-21,-29,-20;
/M: SY='T'; M=  6, -5, -4,-13,-11,-11,-17,-20, -9,-12, -9, -9, -4,-13,-11,-13, 16, 32,  1,-31,-13,-11;
/M: SY='F'; M=-16,-22,-25,-26,-18, 29,-28, -9, -1,-13,  6,  1,-18,-26,-16, -8,-18, -8, -5,  7, 25,-17;
/M: SY='V'; M= -5,-29,-17,-32,-26,  3,-31,-25, 30,-24, 25, 18,-28,-28,-23,-21,-19, -5, 32,-25, -5,-26;
/M: SY='N'; M=-11, 38,-21, 25,  5,-23, -3,  7,-23,  0,-29,-21, 49,-17,  1, -2,  9,  1,-29,-39,-20,  3;
/M: SY='G'; M= -8,  2,-26,  0,-10,-12, 21, -1,-28,-11,-23,-16, 10,-20,-12,-11, -1,-12,-24,-21,-10,-11;
/M: SY='Q'; M= -5, -7,-21,-10, -3,-17,-20, -5, -6, -1, -7, -2, -3,-18,  4,  4, -3, -3, -3,-26,-10,  0;
/M: SY='R'; M=-15,-14,-27,-14, -5, -8,-22, -8,-18, 15,-11, -6, -7,-16, -1, 36,-11, -8,-11,-19, -7, -6;
/M: SY='L'; M= -9,-24,-22,-27,-18, -1,-30,-13, 20,-22, 24, 17,-21,-24,-10,-17,-19, -7, 13,-22, -2,-15;
/I:         E1=0; IE=-105; DE=-105;
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 140 hits in 138 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 135 hits in 133 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 5 hits in 5 different sequences
  • Number of known missed hits: 35
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0
  • Precision (true hits / (true hits + false positives)): 96.43 %
  • Recall (true hits / (true hits + false negatives)): 79.41 %
Comments
  • MATRIX_TYPE: protein_domain
  • Scaling database: UniProtKB/Swiss-Prot: reversed
  • Matrix author: K_Hofmann
  • Taxonomic range: Eukaryotes, Prokaryotes (Bacteria)
  • Maximum known number of repetitions of the pattern in a single protein: 2
  • FT_KEY: DOMAIN
  • FT_DESC: FHA
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
ABA2_NICPL  (Q40412), ABA2_PRUAR  (O81360), ABA2_SOLLC  (P93236), 
ABC1_MYCTU  (O65934), AGGF1_HUMAN (Q8N302), AGGF1_MOUSE (Q7TN31), 
C170B_HUMAN (Q9Y4F5), C170B_MOUSE (Q80U49), C170B_XENLA (Q498L0), 
C170B_XENTR (A0JM08), CDS1_SCHPO  (Q09170), CE170_HUMAN (Q5SW79), 
CE170_MOUSE (Q6A065), CHFR_DANRE  (A5WW08), CHFR_HUMAN  (Q96EP1), 
CHFR_MOUSE  (Q810L3), CHFR_PONAB  (Q5RF77), CHFR_XENLA  (Q5FWP4), 
CHFR_XENTR  (Q6P256), CHK2_CAEEL  (Q9U1Y5), CHK2_HUMAN  (O96017), 
CHK2_MOUSE  (Q9Z265), DDL_ARATH   (Q8W4D8), DMA1_SCHPO  (Q10322), 
DMA1_YEAST  (P38823), DMA2_YEAS7  (A6ZRW7), DMA2_YEAST  (P53924), 
DUN1_YEAST  (P39009), EMBR_MYCBO  (P66800), EMBR_MYCTU  (P66799), 
FAR10_YEAST (Q06001), FHAA_MYCTU  (P71590), FHAB_MYCS2  (A0QNG6), 
FHAB_MYCTU  (P71589), FHAD1_HUMAN (B1AJZ9), FHAD1_MOUSE (A6PWD2), 
FHKA_DICDI  (Q54BF0), FHKB_DICDI  (Q1ZXH2), FHKC_DICDI  (P34101), 
FHKD_DICDI  (Q54MH0), FHKE_DICDI  (Q54VI1), FHL1_SCHPO  (O14270), 
FHL1_YEAST  (P39521), FKH1_YEAST  (P40466), FKH2_SCHPO  (O60129), 
FKH2_YEAST  (P41813), FORJ_DICDI  (Q54ER5), FOXK1_HUMAN (P85037), 
FOXK1_MOUSE (P42128), FOXK2_HUMAN (Q01167), FOXK2_MOUSE (Q3UCQ1), 
FOXK2_XENLA (Q7ZX03), FRAH_NOSS1  (P46017), GARA_MYCS2  (A0QYG2), 
GARA_MYCTU  (P64897), KI67_HUMAN  (P46013), KIF1A_HUMAN (Q12756), 
KIF1A_MOUSE (P33173), KIF1B_HUMAN (O60333), KIF1B_MOUSE (Q60575), 
KIF1B_RAT   (O88658), LOK_DROME   (O61267), MCRS1_HUMAN (Q96EZ8), 
MCRS1_MOUSE (Q99L90), MDC1_HUMAN  (Q14676), MDC1_MACMU  (Q5TM68), 
MDC1_MOUSE  (Q5PSV9), MDC1_PANTR  (Q7YR40), MDC1_PIG    (Q767L8), 
MDC1_RAT    (Q5U2M8), MEK1_SCHPO  (Q10292), MEK1_YEAST  (P24719), 
NADAP_HUMAN (Q9BWU0), NBN_CHICK   (Q9DE07), NBN_DANRE   (Q5I2W8), 
NBN_HUMAN   (O60934), NBN_MOUSE   (Q9R207), NBN_PONAB   (Q5RCV3), 
NBN_RAT     (Q9JIL9), NBS1_SCHPO  (O43070), ODHI_CORDI  (Q6NHD4), 
ODHI_COREF  (Q8FTJ5), ODHI_CORGL  (Q8NQJ3), ODHI_CORJK  (Q4JVU0), 
P2C70_ARATH (P46014), PHF12_HUMAN (Q96QT6), PHF12_MOUSE (Q5SPL2), 
PLM2_YEAST  (Q04383), PML1_YEAST  (Q07930), PP1R8_BOVIN (Q28147), 
PP1R8_HUMAN (Q12972), PP1R8_MOUSE (Q8R3G1), RAD53_YEAST (P22216), 
RNF8A_XENLA (Q7ZX20), RNF8B_XENLA (Q6NRG0), RNF8_BOVIN  (Q2HJ46), 
RNF8_DANRE  (Q803C1), RNF8_HUMAN  (O76064), RNF8_MOUSE  (Q8VC56), 
RNF8_PONAB  (Q5R4I2), RNF8_RAT    (Q4KLN8), SLMAP_HUMAN (Q14BN4), 
SLMAP_MOUSE (Q3URD3), SLMAP_RABIT (Q28623), SLMAP_RAT   (P0C219), 
SNIP1_HUMAN (Q8TAD8), SNIP1_MOUSE (Q8BIZ6), SNIP1_RAT   (Q5M9G6), 
STAR9_MOUSE (Q80TF6), TCF19_HUMAN (Q9Y242), TCF19_MACMU (Q5TM48), 
TCF19_MOUSE (Q99KJ5), TCF19_PANTR (Q7YR48), TCF19_PIG   (Q9TSV4), 
TIFA_BOVIN  (A2VDM0), TIFA_HUMAN  (Q96CG3), TIFA_MOUSE  (Q793I8), 
TIFA_RAT    (Q5XIB9), TIFA_XENLA  (Q2MHQ9), TIFA_XENTR  (B5DE70), 
TOS4_YEAST  (Q06266), VPS64_YEAST (Q03944), Y1858_MYCBO (P64898), 
Y1895_SYNY3 (P74101), Y4449_ARATH (O23305), Y8013_DICDI (Q54VU4), 
YGI1_YEAST  (P53156), YK42_SCHPO  (Q9P7G6), YKI5_CAEEL  (P46012), 
YNVD_SCHPO  (O74388), YOT2_CAEEL  (P34648), ZEP_ARATH   (Q9FGC7), 
ZEP_ORYSJ   (Q0JCU7)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
ABA2_CAPAN  (Q96375), AFAD_HUMAN  (P55196), AFAD_MOUSE  (Q9QZQ1), 
AFAD_RAT    (O35889), KI13A_HUMAN (Q9H1H9), KI13A_MOUSE (Q9EQW7), 
KI13B_HUMAN (Q9NQT8), KI16B_HUMAN (Q96L93), KI16B_MOUSE (B1AVY7), 
KIF14_HUMAN (Q15058), KIF1A_AEDAE (Q17BU3), KIF1A_ANOGA (Q7PHR1), 
KIF1A_DROME (A1ZAJ2), KIF1A_DROPS (Q28WQ1), KIF1C_HUMAN (O43896), 
KIF1C_MOUSE (O35071), KIF1C_RAT   (O35787), KIF1_DICDI  (Q9NGQ2), 
KLP6_HUMAN  (B7ZC32), KLP6_MOUSE  (D3YXS5), KLP6_RAT    (F8WLE0), 
PELI2_HUMAN (Q9HAT8), PELI2_MOUSE (Q8BST6), PHLB1_HUMAN (Q86UU1), 
PHLB1_MOUSE (Q6PDH0), PNKP_HUMAN  (Q96T60), PNKP_MOUSE  (Q9JLV6), 
RADIL_DANRE (A7UA95), RADIL_HUMAN (Q96JH8), RADIL_MOUSE (Q69Z89), 
STAR9_HUMAN (Q9P2P6), TIFAB_HUMAN (Q6ZNK6), TIFAB_MOUSE (Q8JZM6), 
TIFAB_RAT   (Q5BK67), Y7958_DICDI (Q55FT8)
False positive hits (sequences which do not belong to the set under consideration):
CHSAD_CHOCO (Q0VZ70), SYA_FINM2   (B0S104), SYA_RUTMC   (A1AXE0), 
SYA_STAHJ   (Q4L6W5), SYY_RALSO   (Q8Y240)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1DMZ; 1FHQ; 1FHR; 1G3G; 1G6G; 1GXC; 1J4K; 1J4L; 1J4O; 1J4P; 1J4Q; 1K2M; 1K2N; 1K3J; 1K3N; 1K3Q; 1LGP; 1LGQ; 1MZK; 1QU5; 1R21; 1UHT; 2A0T; 2AFF; 2CSW; 2EH0; 2FEZ; 2FF4; 2JKD; 2JPE; 2JQI; 2JQJ; 2JQL; 2KB3; 2KB4; 2KFU; 2KKL; 2LC1; 2PIE; 3EGA; 3ELS; 3ELV; 3HUE; 3HUF; 3I0M; 3I0N; 3I6U; 3I6W; 3OUN; 3PO8; 3POA; 3UMZ; 3UN0; 3UNM; 3UNN; 3UOT; 3VA1; 3VA4; 3VPY; 4EGX; 4EJQ; 4H87;

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