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Entry: PS50006

General information about the entry

Entry name [info] FHA_DOMAIN
Accession [info] PS50006
Entry type [info] MATRIX
Date [info] 01-NOV-1995 CREATED; 10-MAY-2017 DATA UPDATE; 22-NOV-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC50006
Associated ProRule [info] PRU00086

Name and characterization of the entry

Description [info] Forkhead-associated (FHA) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=53; TOPOLOGY=LINEAR;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=48;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.8473000; R2=0.0187000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2669.5043945; R2=1.9115044; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=1; SCORE=410; H_SCORE=3453; N_SCORE=8.5; MODE=1; TEXT='!!';
/CUT_OFF: LEVEL=0; SCORE=330; H_SCORE=3300; N_SCORE=7.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=276; H_SCORE=3197; N_SCORE=6.0; MODE=1; TEXT='?';
/DEFAULT: B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; I=-20; D=-20;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='V'; M= -6,-26,-15,-30,-25,  5,-29,-24, 16,-19,  7,  5,-24,-26,-22,-19,-16, -6, 18, -6,  3,-24;
/M: SY='T'; M= -8,-12,-22,-16,-11, -6,-19,-10, -6, -2, -7, -3, -6,-18, -8,  3, -2,  5, -2,-21, -3,-11;
/M: SY='I'; M=-10,-29,-24,-35,-27, 16,-30,-25, 28,-29, 22, 13,-22,-25,-25,-24,-20,-10, 19,-15,  3,-27;
/M: SY='G'; M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='R'; M=-19, -8,-30, -8,  1,-21,-20,  5,-30, 29,-21, -9,  1,-19, 10, 62,-10,-11,-21,-21, -8,  1;
/M: SY='N'; M= -6,  4,-23, -2, -6,-16, -7,  1,-15, -3,-21,-12, 15,-10, -3,  2,  4, -3,-16,-27, -9, -7;
/M: SY='S'; M=  3, -1,-18, -4, -2,-18,-14,-14,-12, -3,-17,-12,  1, -8, -4, -5, 11, 11, -5,-30,-15, -4;
/M: SY='D'; M= -6, 16,-25, 24, 17,-29,-12, -7,-28,  3,-26,-21,  6,  1,  2, -6,  7,  1,-22,-34,-19,  9;
/I:         MI=-12; MD=-12; IM=-12; I=-4;
/M: SY='R'; D=-2; M= -6,  1,-17,  0,  3,-16, -5, -2,-14,  4,-13, -8,  6, -6,  6,  7,  1, -4,-15,-19,-11,  4;
/I:         DM=-12;
/M: SY='C'; M= -4,-20, 45,-25,-23,-14,-22,-26, -9,-22,-10, -9,-18,-26,-23,-21, -6, -5,  5,-38,-21,-24;
/M: SY='D'; M=-18, 42,-29, 56, 20,-38,-10,  2,-36,  1,-29,-26, 21,-11,  7, -7,  1, -9,-30,-38,-19, 13;
/M: SY='V'; M= -5,-27,-10,-29,-25, -1,-26,-23, 20,-22, 15, 10,-25,-28,-21,-20,-15, -6, 25,-24, -5,-24;
/M: SY='A'; M=  2, -3,-19, -6, -7,-12,-14, -6,-10, -4,-11, -8,  0,-17, -7, -3,  2,  0, -5,-25, -7, -8;
/I:         MD=-10;
/M: SY='L'; D=-3; M= -2,-11,-13,-11, -6, -3, -9, -5,  1,-12, 11,  6,-10,-14, -6, -9, -7, -4, -1,-15, -4, -6;
/I:         MI=0; IM=0; DM=-10; I=-5;
/M: SY='L'; M= -6,-21,-17,-25,-20,  3, -2,-19, -2,-23,  7,  4,-16,-24,-17,-19,-14,-12, -4,-17, -6,-19;
/M: SY='E'; M=-10,  9,-28, 12, 16,-27,-11, -5,-25,  6,-22,-16,  7,  1,  5,  0,  0, -5,-24,-30,-18, 10;
/M: SY='S'; M=  0,  5,-22,  6,  0,-23, -2, -5,-20,-10,-21,-16,  7, -3, -4,-12, 10, -1,-17,-33,-18, -3;
/M: SY='P'; M= -8, -5,-29, -4,  4,-26,-11, -9,-23, 10,-26,-12, -2, 15,  3,  5, -1, -6,-22,-27,-19,  2;
/M: SY='V'; M= -8,-11,-19,-12,-12,  1,-21,-15,  0,-10, -3, -3, -8,-22,-14, -4, -4, -3,  6,-24, -6,-13;
/M: SY='I'; M= -7,-30,-22,-35,-28,  2,-35,-28, 38,-27, 22, 17,-25,-25,-23,-25,-19, -7, 33,-23, -3,-28;
/M: SY='S'; M= 10,  0,-10,  0,  0,-20,  0,-10,-20,-10,-30,-20, 10,-10,  0,-10, 40, 20,-10,-40,-20,  0;
/M: SY='R'; M=-14, -4,-27, -6, -2,-21, -8, -3,-29, 20,-22,-12,  6,-19,  5, 46, -4, -6,-21,-23,-13, -2;
/M: SY='R'; M=-10, -9,-15,-14,-11, -6,-22,-10, -5,  2, -9, -2, -4,-22, -7,  4, -8, -4,  1,-22, -4,-10;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='A'; M= 23,-15, 21,-24,-18,-10, -9,-23,-14,-18, -9,-11,-14,-21,-19,-23,  0, -5, -3,-25,-18,-18;
/M: SY='Q'; M= -6, -7,-14, -8,  4,-17,-21, -9,-12, -2,-10, -6, -7,-16,  7,  0, -5, -7,-10,-24,-11,  5;
/M: SY='I'; M=-10,-30,-23,-36,-28, 13,-35,-26, 33,-29, 25, 16,-24,-25,-24,-25,-21, -9, 24,-17,  3,-28;
/M: SY='Y'; M=-11,-10,-23,-13, -5,  3,-20,  5,-16, -5,-11, -7, -5,-18, -4,  0, -3, -1,-14,-10,  6, -5;
/M: SY='Y'; M=-10,-21, -6,-24,-19,  8,-27, -5, -2,-15,  2,  0,-19,-27,-14,-14,-16,-10, -2, -3, 19,-18;
/M: SY='D'; M=-10, 11,-26, 12,  6,-24,  0, -1,-23, -3,-18,-14,  9,-15,  0, -6, -2, -7,-21,-30,-16,  3;
/I:         MD=-10;
/M: SY='P'; D=-3; M=-10, -5,-22, -6, -2, -3,-15, -3,-12, -7,-10, -6, -2,  6, -5, -5, -6, -6,-15,-19, -6, -4;
/I:         MD=-10;
/M: SY='Q'; D=-3; M= -8,  0,-16, -2,  0,-10,-10,  2,-12, -2, -7, -3,  1,-11,  4,  1, -2,  0,-11,-16, -4,  2;
/I:         MI=0; IM=0; DM=-10; I=-5;
/M: SY='D'; M= -7,  4,-23,  6,  5,-22, -9,-10,-18, -2,-18,-13,  3,-13,  0, -2,  5,  2,-13,-30,-16,  2;
/M: SY='G'; M= -7, -1,-30, -3, -4,-22, 10,-11,-27, -5,-26,-17,  4,  0, -5, -7, -4,-12,-27,-15,-18, -5;
/M: SY='R'; M= -4, -2,-24, -5,  4,-20, -8, -2,-20,  7,-16, -8,  2,-15,  1, 10, -2, -6,-15,-25,-13,  1;
/M: SY='W'; M=-10,-28,-27,-31,-24, 15,-26,-17,  4,-20,  1, -1,-25,-27,-19,-18,-20,-12,  4, 27, 14,-20;
/M: SY='Y'; M=-10,-10,-25,-10, -3,  3,-16,  3,-10, -9, -7, -6, -6,-19, -6, -9, -5, -6,-12,-10, 15, -6;
/M: SY='L'; M= -8,-30,-21,-33,-24,  6,-33,-24, 30,-28, 35, 18,-27,-27,-22,-23,-24, -8, 22,-22, -2,-24;
/M: SY='H'; M=-11,  1,-27,  2, 11,-19,-19, 14,-21,  5,-18, -9,  3,-14,  8,  8, -4, -9,-19,-26, -6,  8;
/M: SY='D'; M=-16, 27,-14, 37,  8,-30,-17, -7,-23, -7,-21,-20, 10,-15, -6,-14, -3, -9,-17,-38,-18,  0;
/I:         MI=0; IM=0; I=-8;
/M: SY='A'; M= -8,-14,-18,-17,-14, -8, -5, -7,-10,-10, -6, -3, -8,-20,-13,-10, -8, -8, -8,-22, -7,-14;
/M: SY='S'; M=  7, -3,-16, -3, -6,-23, 20,-13,-26,-13,-30,-20,  7,-13, -6,-13, 29,  9,-16,-34,-23, -6;
/M: SY='T'; M= -2, -4,-17, -7, -1,-16,-15,-11,-15,  2,-14, -8, -1,-13, -1,  5, 11, 14, -8,-29,-12, -1;
/M: SY='N'; M= -9, 32,-20, 16,  1,-21, -2, 13,-21, -1,-29,-18, 50,-19,  4,  0, 11,  0,-28,-38,-17,  2;
/M: SY='G'; M= -1,-12,-29,-11,-20,-28, 59,-21,-35,-19,-28,-18, -3,-15,-20,-20, -1,-18,-25,-21,-29,-20;
/M: SY='T'; M=  6, -5, -4,-13,-11,-11,-17,-20, -9,-12, -9, -9, -4,-13,-11,-13, 16, 32,  1,-31,-13,-11;
/M: SY='F'; M=-16,-22,-25,-26,-18, 29,-28, -9, -1,-13,  6,  1,-18,-26,-16, -8,-18, -8, -5,  7, 25,-17;
/M: SY='V'; M= -5,-29,-17,-32,-26,  3,-31,-25, 30,-24, 25, 18,-28,-28,-23,-21,-19, -5, 32,-25, -5,-26;
/M: SY='N'; M=-11, 38,-21, 25,  5,-23, -3,  7,-23,  0,-29,-21, 49,-17,  1, -2,  9,  1,-29,-39,-20,  3;
/M: SY='G'; M= -8,  2,-26,  0,-10,-12, 21, -1,-28,-11,-23,-16, 10,-20,-12,-11, -1,-12,-24,-21,-10,-11;
/M: SY='Q'; M= -5, -7,-21,-10, -3,-17,-20, -5, -6, -1, -7, -2, -3,-18,  4,  4, -3, -3, -3,-26,-10,  0;
/M: SY='R'; M=-15,-14,-27,-14, -5, -8,-22, -8,-18, 15,-11, -6, -7,-16, -1, 36,-11, -8,-11,-19, -7, -6;
/M: SY='L'; M= -9,-24,-22,-27,-18, -1,-30,-13, 20,-22, 24, 17,-21,-24,-10,-17,-19, -7, 13,-22, -2,-15;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_11 which contains 556'196 sequence entries.


Total number of hits 156 in 154 different sequences
Number of true positive hits 151 in 149 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 36
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 96.79 %
Recall (true positives / (true positives + false negatives)) 80.75 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 2
Feature key [info] DOMAIN
Feature description [info] FHA
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
149 sequences

ABA2_NICPL  (Q40412    ), ABA2_PRUAR  (O81360    ), ABA2_SOLLC  (P93236    ), 
ABA2_SPIOL  (A0A0K9RDW0), ABC1_MYCTU  (O65934    ), AGGF1_HUMAN (Q8N302    ), 
AGGF1_MOUSE (Q7TN31    ), C170B_HUMAN (Q9Y4F5    ), C170B_MOUSE (Q80U49    ), 
C170B_XENLA (Q498L0    ), C170B_XENTR (A0JM08    ), CDS1_SCHPO  (Q09170    ), 
CE170_HUMAN (Q5SW79    ), CE170_MOUSE (Q6A065    ), CHFR_DANRE  (A5WW08    ), 
CHFR_HUMAN  (Q96EP1    ), CHFR_MOUSE  (Q810L3    ), CHFR_PONAB  (Q5RF77    ), 
CHFR_XENLA  (Q5FWP4    ), CHFR_XENTR  (Q6P256    ), CHK2_CAEEL  (Q9U1Y5    ), 
CHK2_HUMAN  (O96017    ), CHK2_MOUSE  (Q9Z265    ), DDL_ARATH   (Q8W4D8    ), 
DMA1_SCHPO  (Q10322    ), DMA1_YEAST  (P38823    ), DMA2_YEAS7  (A6ZRW7    ), 
DMA2_YEAST  (P53924    ), DUN1_YEAST  (P39009    ), EMBR_MYCBO  (P66800    ), 
EMBR_MYCTO  (P9WGJ8    ), EMBR_MYCTU  (P9WGJ9    ), FAR10_YEAST (Q06001    ), 
FHA1_ARATH  (Q9SFV6    ), FHA1_TOBAC  (Q945P0    ), FHA2_ARATH  (Q9SFV2    ), 
FHAA_MYCTU  (P71590    ), FHAB_MYCS2  (A0QNG6    ), FHAB_MYCTO  (P9WJB4    ), 
FHAB_MYCTU  (P9WJB5    ), FHAD1_HUMAN (B1AJZ9    ), FHAD1_MOUSE (A6PWD2    ), 
FHKA_DICDI  (Q54BF0    ), FHKB_DICDI  (Q1ZXH2    ), FHKC_DICDI  (P34101    ), 
FHKD_DICDI  (Q54MH0    ), FHKE_DICDI  (Q54VI1    ), FHL1_CANAL  (Q59ZC8    ), 
FHL1_SCHPO  (O14270    ), FHL1_YEAST  (P39521    ), FKH1_YEAST  (P40466    ), 
FKH2_CANAL  (Q5A7S7    ), FKH2_SCHPO  (O60129    ), FKH2_YEAST  (P41813    ), 
FORJ_DICDI  (Q54ER5    ), FOXK1_HUMAN (P85037    ), FOXK1_MOUSE (P42128    ), 
FOXK2_HUMAN (Q01167    ), FOXK2_MOUSE (Q3UCQ1    ), FOXK2_XENLA (Q7ZX03    ), 
FRAH_NOSS1  (P46017    ), GARA_MYCS2  (A0QYG2    ), GARA_MYCTO  (P9WJA8    ), 
GARA_MYCTU  (P9WJA9    ), KI67_HUMAN  (P46013    ), KI67_MOUSE  (E9PVX6    ), 
KIF14_MOUSE (L0N7N1    ), KIF1A_HUMAN (Q12756    ), KIF1A_MOUSE (P33173    ), 
KIF1B_HUMAN (O60333    ), KIF1B_MOUSE (Q60575    ), KIF1B_RAT   (O88658    ), 
LOK_DROME   (O61267    ), MCRS1_HUMAN (Q96EZ8    ), MCRS1_MOUSE (Q99L90    ), 
MDC1_HUMAN  (Q14676    ), MDC1_MACMU  (Q5TM68    ), MDC1_MOUSE  (Q5PSV9    ), 
MDC1_PANTR  (Q7YR40    ), MDC1_PIG    (Q767L8    ), MDC1_RAT    (Q5U2M8    ), 
MEK1_SCHPO  (Q10292    ), MEK1_YEAST  (P24719    ), NADAP_HUMAN (Q9BWU0    ), 
NBN_CHICK   (Q9DE07    ), NBN_DANRE   (Q5I2W8    ), NBN_HUMAN   (O60934    ), 
NBN_MOUSE   (Q9R207    ), NBN_PONAB   (Q5RCV3    ), NBN_RAT     (Q9JIL9    ), 
NBS1_ARATH  (Q0H8D7    ), NBS1_ORYSI  (B8BHK8    ), NBS1_ORYSJ  (Q7XD82    ), 
NBS1_SCHPO  (O43070    ), ODHI_CORDI  (Q6NHD4    ), ODHI_COREF  (Q8FTJ5    ), 
ODHI_CORGL  (Q8NQJ3    ), ODHI_CORJK  (Q4JVU0    ), P2C70_ARATH (P46014    ), 
PHF12_HUMAN (Q96QT6    ), PHF12_MOUSE (Q5SPL2    ), PLM2_YEAST  (Q04383    ), 
PML1_YEAST  (Q07930    ), PP1R8_ARATH (Q9FIK2    ), PP1R8_BOVIN (Q28147    ), 
PP1R8_HUMAN (Q12972    ), PP1R8_MOUSE (Q8R3G1    ), PS1_ARATH   (B7SY83    ), 
RAD53_YEAST (P22216    ), RNF8A_XENLA (Q7ZX20    ), RNF8B_XENLA (Q6NRG0    ), 
RNF8_BOVIN  (Q2HJ46    ), RNF8_DANRE  (Q803C1    ), RNF8_HUMAN  (O76064    ), 
RNF8_MOUSE  (Q8VC56    ), RNF8_PONAB  (Q5R4I2    ), RNF8_RAT    (Q4KLN8    ), 
SLMAP_HUMAN (Q14BN4    ), SLMAP_MOUSE (Q3URD3    ), SLMAP_RABIT (Q28623    ), 
SLMAP_RAT   (P0C219    ), SNIP1_HUMAN (Q8TAD8    ), SNIP1_MOUSE (Q8BIZ6    ), 
SNIP1_RAT   (Q5M9G6    ), STAR9_MOUSE (Q80TF6    ), TCF19_HUMAN (Q9Y242    ), 
TCF19_MACMU (Q5TM48    ), TCF19_MOUSE (Q99KJ5    ), TCF19_PANTR (Q7YR48    ), 
TCF19_PIG   (Q9TSV4    ), TIFA_BOVIN  (A2VDM0    ), TIFA_HUMAN  (Q96CG3    ), 
TIFA_MOUSE  (Q793I8    ), TIFA_RAT    (Q5XIB9    ), TIFA_XENLA  (Q2MHQ9    ), 
TIFA_XENTR  (B5DE70    ), TOS4_YEAST  (Q06266    ), VPS64_YEAST (Q03944    ), 
Y1858_MYCBO (P64898    ), Y1895_SYNY3 (P74101    ), Y4449_ARATH (O23305    ), 
Y8013_DICDI (Q54VU4    ), YGI1_YEAST  (P53156    ), YK42_SCHPO  (Q9P7G6    ), 
YKI5_CAEEL  (P46012    ), YNVD_SCHPO  (O74388    ), YOT2_CAEEL  (P34648    ), 
ZEP_ARATH   (Q9FGC7    ), ZEP_ORYSJ   (Q0JCU7    )
» more

UniProtKB/Swiss-Prot
False negative sequences
36 sequences

ABA2_CAPAN  (Q96375    ), AFAD_HUMAN  (P55196    ), AFAD_MOUSE  (Q9QZQ1    ), 
AFAD_RAT    (O35889    ), KI13A_HUMAN (Q9H1H9    ), KI13A_MOUSE (Q9EQW7    ), 
KI13B_HUMAN (Q9NQT8    ), KI16B_HUMAN (Q96L93    ), KI16B_MOUSE (B1AVY7    ), 
KIF14_HUMAN (Q15058    ), KIF1A_AEDAE (Q17BU3    ), KIF1A_ANOGA (Q7PHR1    ), 
KIF1A_DROME (A1ZAJ2    ), KIF1A_DROPS (Q28WQ1    ), KIF1C_HUMAN (O43896    ), 
KIF1C_MOUSE (O35071    ), KIF1C_RAT   (O35787    ), KIF1_DICDI  (Q9NGQ2    ), 
KIF28_HUMAN (B7ZC32    ), KIF28_MOUSE (D3YXS5    ), KIF28_RAT   (F8WLE0    ), 
PELI2_HUMAN (Q9HAT8    ), PELI2_MOUSE (Q8BST6    ), PHLB1_HUMAN (Q86UU1    ), 
PHLB1_MOUSE (Q6PDH0    ), PNKP_HUMAN  (Q96T60    ), PNKP_MOUSE  (Q9JLV6    ), 
RADIL_DANRE (A7UA95    ), RADIL_HUMAN (Q96JH8    ), RADIL_MOUSE (Q69Z89    ), 
STAR9_HUMAN (Q9P2P6    ), TIFAB_HUMAN (Q6ZNK6    ), TIFAB_MOUSE (Q8JZM6    ), 
TIFAB_RAT   (Q5BK67    ), Y7958_DICDI (Q55FT8    ), ZEP_ONCHC   (C3VEQ2    )
» more

UniProtKB/Swiss-Prot
False positive sequences
5 sequences

CHSAD_CHOCO (Q0VZ70    ), SYA_FINM2   (B0S104    ), SYA_RUTMC   (A1AXE0    ), 
SYA_STAHJ   (Q4L6W5    ), SYY_RALSO   (Q8Y240    )
» more

PDB
[Detailed view]
68 PDB

1DMZ; 1FHQ; 1FHR; 1G3G; 1G6G; 1GXC; 1J4K; 1J4L; 1J4O; 1J4P; 1J4Q; 1K2M; 1K2N; 1K3J; 1K3N; 1K3Q; 1LGP; 1LGQ; 1MZK; 1QU5; 1R21; 1UHT; 2A0T; 2AFF; 2CSW; 2EH0; 2FEZ; 2FF4; 2JKD; 2JPE; 2JQI; 2JQJ; 2JQL; 2KB3; 2KB4; 2KFU; 2KKL; 2LC1; 2PIE; 3EGA; 3ELS; 3ELV; 3HUE; 3HUF; 3I0M; 3I0N; 3I6U; 3I6W; 3OUN; 3PO8; 3POA; 3UMZ; 3UN0; 3UNM; 3UNN; 3UOT; 3VA1; 3VA4; 3VPY; 4EGX; 4EJQ; 4H87; 4JON; 4QCJ; 4YM4; 4ZGI; 5LQW; 5T2S
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission