PROSITE entry PS52051

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS52051
Entry name [info]	CXC_MSL2
Accession [info]	PS52051
Entry type [info]	MATRIX
Date [info]	05-FEB-2025 CREATED; 05-FEB-2025 DATA UPDATE; 05-FEB-2025 INFO UPDATE.
PROSITE Doc. [info]	PDOC52051
Associated ProRule [info]	PRU01396

Name and characterization of the entry

Description [info]

CXC MSL2-type domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=52;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=47;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.9816434; R2=0.0081472; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1046; N_SCORE=12.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=310; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-51; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M= -26, -83, -73, -11, -75,  -9, -75,  -4,   5,  -6, -19,   3,  34,  -5, -20, -30, -12,  24, -89, -76;
/M: SY='E';  M=  -9, -86, -62,  45, -43, -65, -69, -38,  44, -54, -10, -66,  15,   2,  17, -59,  -8, -42, -85, -76;
/M: SY='K';  M= -47, -87, -71, -60, -54, -27, -69, -39,  63, -36, -71, -64,  16, -56,  52,  -1, -67, -38, -84, -74;
/M: SY='K';  M= -48, -89, -27, -17, -88, -49,  21, -78,  66, -87, -75, -45,  33,   7,  29, -18, -62, -85, -20, -74;
/M: SY='G';  M= -64, -84, -73, -77, -80,  60, -23,  10,  -5, -29, -70,  -3, -26, -71, -15, -19,  11, -29, -87, -78;
/M: SY='C';  M= -71, 144, -91, -91, -81, -86, -91, -88, -86, -78, -79, -77,-101, -94, -93, -73, -71, -75,-111, -92;
/M: SY='R';  M= -72, -89, -69, -58, -87, -42, -64, -91,  59, -86, -75, -62, -79, -50,  83,  -9, -70, -85, -84, -74;
/M: SY='C';  M= -71, 144, -91, -91, -81, -86, -91, -88, -86, -78, -79, -77,-101, -94, -93, -73, -71, -75,-111, -92;
/M: SY='G';  M= -34, -86, -74, -84, -92,  91, -80, -99, -76, -95, -84, -60, -78, -75, -24, -59, -77, -92, -83, -87;
/I:         I=-36; MD=-90;
/M: SY='R';  M= -49, -88, -75, -75, -83, -34, -75,  -9, -22, -44, -16,  38, -87,  -6,  39, -31,  21,  -5, -97, -59; D=-36;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='A';  M=  55, -75, -73, -68, -55, -26, -75, -72, -32, -77, -72, -23, -76, -14, -10,  35,  11, -12,   1, -76;
/M: SY='T';  M= -51, -75, -38, -70, -15,  13, -74, -72, -19, -77, -73,   5, -73, -68, -73,  35,  71, -21, -91, -73;
/M: SY='Q';  M= -16, -24, -70, -61, -84, -14, -22, -40,  17, -41, -15, -36,  29,  59, -45,  12,  12, -17, -87, -75;
/M: SY='N';  M=  19, -21, -65, -45, -40,  -5, -68, -47, -46, -14, -10,  57, -79,   0, -44,  -2,  23, -32, -89, -43;
/M: SY='P';  M= -72, -92, -69, -63, -91, -30, -72, -80,  11, -89, -77,  30,  96,   9, -70, -50, -39, -31, -90, -86;
/M: SY='G';  M= -58, -81, -69, -72, -87,  57, -73, -85, -20, -88, -80,  -5,   5, -29, -74,  56, -16, -39, -88, -81;
/M: SY='K';  M= -46, -82, -73, -42, -75, -52,  -9, -52,  48,   0, -63, -44,   6, -31,  11,  -5,  -5,  27, -88, -72;
/I:         I=-38; MD=-97;
/M: SY='L';  M= -42, -33, -81, -78, -65, -86, -76, -58, -23,  54, -22,   4, -88, -73,   6, -15,  22, -61, -89, -71; D=-38;
/I:         I=-38; MD=-97;
/M: SY='T';  M= -72, -81, -78, -81, -87, -88, -88, -76, -77, -82, -79, -67, -79, -82, -86, -56,  94, -37,-108, -85; D=-38;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='C';  M= -71, 144, -91, -91, -81, -86, -91, -88, -86, -78, -79, -77,-101, -94, -93, -73, -71, -75,-111, -92;
/M: SY='R';  M= -73,  70, -79, -70, -19, -69, -22, -16, -31, -26, -67, -70, -87, -23,  78, -26, -71, -14, -87, -54;
/M: SY='G';  M= -61, -82, -65, -78, -89,  77, -72, -93, -71, -93, -82,  48, -78, -71, -47, -14,  -2, -88, -88, -84;
/M: SY='Q';  M= -67, -86, -62, -54, -81, -73, -11, -81, -15, -80, -70,  34, -77,  93, -56,  13,  11, -81, -80,  23;
/M: SY='R';  M= -76, -92, -72, -60, -86, -86, -62, -92,   7, -85, -74, -65, -84, -49, 104, -70, -75, -86, -85, -72;
/M: SY='C';  M= -71, 143, -91, -91, -79, -87, -90, -85, -87, -42, -76, -77,-101, -94, -93, -74, -71, -74,-109, -90;
/M: SY='P';  M= -46, -96, -76, -66, -87, -77, -76, -64, -69, -67, -77, -78, 106, -44, -16,  -6, -22, -83,   0, -22;
/I:         I=-31; MD=-79;
/M: SY='C';  M= -72, 143, -92, -92, -82, -88, -92, -89, -88, -80, -80, -78,-103, -96, -94, -75, -72, -77,-112, -93; D=-31;
/I:         I=-31; MD=-79;
/M: SY='Y';  M= -83, -91, -84, -86,  37, -90, -51, -66, -78, -62, -61, -84, -95, -75, -75, -78, -77, -71, -40, 117; D=-31;
/I:         I=-31; MD=-79;
/M: SY='S';  M= -12, -69, -64, -58, -69, -64, -66,  -7,  55, -62,  -3, -55, -68, -54, -51,  63, -12,  40, -81, -65; D=-31;
/I:         I=-31; MD=-79;
/M: SY='N';  M=  12, -70,  27,  20, -78, -32, -53, -71, -11, -77, -69,  88, -69, -31, -58,  20, -13, -14, -89, -71; D=-31;
/I:         I=-31; MD=-79;
/M: SY='F';  M= -40, -77,  11,   4,  55,  42, -52, -74,   7, -69, -67, -11, -72,   2,  33,  13, -62, -72, -67, -18; D=-31;
/I:         I=-31; MI=-79; MD=-79; IM=-79; DM=-79;
/M: SY='N';  M= -26, -74, -51, -53, -73, -12, -55, -72,  70, -22, -64,  78, -70, -17, -20, -53, -13, -38, -80, -17; D=-31;
/I:         I=-31; DM=-79;
/M: SY='S';  M=  14, -68, -59, -23, -65, -17, -63, -68, -43, -74, -68, -52,  40, -53, -39,  87, -23, -11, -82, -69;
/M: SY='C';  M= -62, 149, -80, -78, -72, -77, -79, -79, -32, -70, -69, -67, -91, -80,  -4, -64, -62, -67, -99, -81;
/I:         I=-20; MD=-51;
/M: SY='A';  M=  44, -70, -19,  31, -48, -66,   6,  -2,  -6,  -9, -33, -12, -68, -36, -11,  -3,  22,  -4, -77,  -1; D=-20;
/I:         I=-20; MI=0; MD=-51; IM=0; DM=-51;
/M: SY='D';  M= -51, -14,  86,   5, -79,  14,  30, -80, -11, -52, -41,  36, -69, -22, -24,  -9, -58, -53, -90, -26;
/M: SY='C';  M= -36, 148, -82, -82,  -8, -77, -80, -77, -78, -68, -69, -69, -92, -85, -83, -65, -63, -66, -93, -17;
/M: SY='H';  M= -21, -77, -61, -56, -68, -47,  92, -13,  41, -25, -58,   3,  19, -34,  21,   4, -59,  -3, -82, -12;
/M: SY='C';  M= -36, 148, -83, -83, -72, -79, -83, -76, -79, -42, -69, -70, -93, -86, -85, -66, -63, -34,-101, -83;
/M: SY='V';  M= -52,  15, -70, -41,   3, -79, -31, -14,  11, -18, -54,  -3, -77,  20,  50, -63, -12,  57, -80, -61;
/M: SY='G';  M= -19,   2, -62, -75, -84,  87, -69, -89, -68, -87, -77,  44, -72, -67, -76, -35, -29, -83, -81, -80;
/M: SY='C';  M= -37, 147, -82, -82, -75, -79,  -7, -81, -45, -73, -72, -69, -46, -84, -83, -66, -64, -70,-103, -83;
/M: SY='K';  M= -25, -81, -61, -51, -81,   7,  36, -83,  72, -79, -68, -15, -70,  17,  53, -58, -13, -78, -79, -66;
/M: SY='N';  M= -38, -71, -40, -60, -80, -54, -47, -78, -31, -63, -72, 119, -76, -53, -59, -48, -50, -80, -98, -75;
/M: SY='P';  M= -67, -92, -69, -38, -86, -70, -73, -77, -66, -86, -74, -73, 118, -68, -77,  -5, -19, -81,  19, -82;
/M: SY='H';  M= -41, -81, -66, -64,  29, -77, 112, -68, -61,  -2, -54, -18, -79, -45,  17, -65, -42, -40, -71,  52;
/M: SY='K';  M= -64, -79, -19,  -3, -78, -11, -61, -31,  74, -59,  19,  25,  -6, -14,   0, -41,  13, -62, -80, -59;
/M: SY='E';  M=-130,-151,-101,  42,-154,-146,-123,-155,-111,-147,-143,-127,-125,-104,-121,-127,-131,-147,-150,-144;
/M: SY='D';  M=-138,-151,  49,-101,-158,-134,-123,-156,-125,-155,-154,-105,-137,-124,-133,-126,-127,-153,-173,-141;
/M: SY='Y';  M=-141,-152,-141,-144, -89,-148,-107,-127,-135,-123,-120,-142,-153,-131,-132,-136,-136,-132, -97,  64;
/M: SY='V';  M=-122,-136,-153,-147,-124,-154,-156, -89,-145,-110,-112,-149,-149,-148,-146,-136,-121,  33,-158,-132;
/M: SY='E';  M=-130,-151,-101,  42,-154,-146,-123,-155,-111,-147,-143,-127,-125,-104,-121,-127,-131,-147,-150,-144;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	4 in 4 different sequences
Number of true positive hits	4 in 4 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	CXC MSL2-type
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

4 sequences

MSL2_CHICK  (A0A1D5NVS8), MSL2_DROME  (P50534), MSL2_HUMAN  (Q9HCI7),

MSL2_MOUSE  (Q69ZF8)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

3 PDB

2LUA; 4RKG; 4RKH