We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00004cAMP- and cGMP-dependent protein kinase phosphorylation site
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00004
Description
There has been a number of studies relative to the specificity of cAMP- and cGMP-dependent protein kinases [1,2,3]. Both types of kinases appear to share a preference for the phosphorylation of serine or threonine residues found close to at least two consecutive N-terminal basic residues. It is important to note that there are quite a number of exceptions to this rule.
Last update:June 1988 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Fremisco J.R. Glass D.B. Krebs E.G. |
| Source | J. Biol. Chem. 255:4240-4245(1980). |
| 2 | Authors | Glass D.B. Smith S.B. |
| Title | Phosphorylation by cyclic GMP-dependent protein kinase of a synthetic peptide corresponding to the autophosphorylation site in the enzyme. | |
| Source | J. Biol. Chem. 258:14797-14803(1983). | |
| PubMed ID | 6317673 |
| 3 | Authors | Glass D.B. el-Maghrabi M.R. Pilkis S.J. |
| Title | Synthetic peptides corresponding to the site phosphorylated in 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as substrates of cyclic nucleotide-dependent protein kinases. | |
| Source | J. Biol. Chem. 261:2987-2993(1986). | |
| PubMed ID | 3005275 |
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