In prokaryotes, membrane lipoproteins are synthesized with a precursor signal
peptide, which is cleaved by a specific lipoprotein signal peptidase (signal
peptidase II). The peptidase recognizes a conserved sequence and cuts upstream
of a cysteine residue to which a glyceride-fatty acid lipid is attached [1].
Some of the proteins known to undergo such processing currently include (for
recent listings see [1,2,3]):
Major outer membrane lipoprotein (murein-lipoproteins) (gene lpp).
Escherichia coli lipoprotein-28 (gene nlpA).
Escherichia coli lipoprotein-34 (gene nlpB).
Escherichia coli lipoprotein nlpC.
Escherichia coli lipoprotein nlpD.
Escherichia coli osmotically inducible lipoprotein B (gene osmB).
Escherichia coli osmotically inducible lipoprotein E (gene osmE).
Escherichia coli rare lipoproteins A and B (genes rplA and rplB).
Escherichia coli copper homeostasis protein cutF (or nlpE).
Escherichia coli plasmids traT proteins.
Escherichia coli Col plasmids lysis proteins.
A number of Bacillus β-lactamases.
Bacillus subtilis periplasmic oligopeptide-binding protein (gene oppA).
Borrelia burgdorferi outer surface proteins A and B (genes ospA and ospB).
Borrelia hermsii variable major protein 21 (gene vmp21) and 7 (gene vmp7).
Chlamydia trachomatis outer membrane protein 3 (gene omp3).
Fibrobacter succinogenes endoglucanase cel-3.
Haemophilus influenzae proteins Pal and Pcp.
Klebsiella pullulunase (gene pulA).
Klebsiella pullulunase secretion protein pulS.
Mycoplasma hyorhinis protein p37.
Mycoplasma hyorhinis variant surface antigens A, B, and C (genes vlpABC).
Neisseria outer membrane protein H.8.
Pseudomonas aeruginosa lipopeptide (gene lppL).
Pseudomonas solanacearum endoglucanase egl.
Rhodopseudomonas viridis reaction center cytochrome subunit (gene cytC).
Rickettsia 17 Kd antigen.
Shigella flexneri invasion plasmid proteins mxiJ and mxiM.
Streptococcus pneumoniae oligopeptide transport protein A (gene amiA).
Treponema pallidium 34 Kd antigen.
Treponema pallidium membrane protein A (gene tmpA).
Vibrio harveyi chitobiase (gene chb).
Yersinia virulence plasmid protein yscJ.
Halocyanin from Natrobacterium pharaonis [4], a membrane associated copper-
binding protein. This is the first archaebacterial protein known to be
modified in such a fashion).
From the precursor sequences of all these proteins, we derived a profile that
starts at the beginning of the sequence and ends after the
post-translationally modified cysteine.
Note:
This profile replace an obsolete rule. All the information in the rule
has been encoded in the profile format.
Last update:
October 2006 / Text revised; profiles added; rule deleted.
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