PROSITE documentation PDOC00046
Histone H4 signature


Histone H4 is one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core. Along with H3, it plays a central role in nucleosome formation. The sequence of histone H4 has remained almost invariant in more then 2 billion years of evolution [1,E1]. The region we use as a signature pattern is a pentapeptide found in positions 14 to 18 of all H4 sequences. It contains a lysine residue which is often acetylated [2] and a histidine residue which is implicated in DNA-binding [3].

Last update:

November 1995 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

HISTONE_H4, PS00047; Histone H4 signature  (PATTERN)


1AuthorsThatcher T.H. Gorovsky M.A.
TitlePhylogenetic analysis of the core histones H2A, H2B, H3, and H4.
SourceNucleic Acids Res. 22:174-179(1994).
PubMed ID8121801

2AuthorsDoenecke D. Gallwitz D.
TitleAcetylation of histones in nucleosomes.
SourceMol. Cell. Biochem. 44:113-128(1982).
PubMed ID6808351

3AuthorsEbralidse K.K. Grachev S.A. Mirzabekov A.D.
TitleA highly basic histone H4 domain bound to the sharply bent region of nucleosomal DNA.
SourceNature 331:365-367(1988).
PubMed ID3340182


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