PROSITE documentation PDOC00047
Protamine P1 signature


Protamines are small, highly basic proteins, that substitute for histones in sperm chromatin during the haploid phase of spermatogenesis. They pack sperm DNA into a highly condensed, stable and inactive complex. There are two different types of mammalian protamine, called P1 and P2. P1 has been found in all species studied, while P2 is sometimes absent. There seems to be a single type of avian protamine whose sequence is closely related to that of mammalian P1 [1].

As a signature for this family of proteins, we selected a conserved region at the N-terminal extremity of the sequence.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PROTAMINE_P1, PS00048; Protamine P1 signature  (PATTERN)


1AuthorsOliva R. Goren R. Dixon G.H.
TitleQuail (Coturnix japonica) protamine, full-length cDNA sequence, and the function and evolution of vertebrate protamines.
SourceJ. Biol. Chem. 264:17627-17630(1989).
PubMed ID2808336

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