We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00049Ribosomal protein L23 signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00049
Description
Ribosomal protein L23 is one of the proteins from the large ribosomal subunit. In Escherichia coli, L23 is known to bind a specific region on the 23S rRNA; in yeast, the corresponding protein binds to a homologous site on the 26S rRNA [1]. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [2,3,4], groups:
- Eubacterial L23.
- Algal and plant chloroplast L23.
- Archaebacterial L23.
- Mammalian L23A.
- Caenorhabditis elegans L23A (F55D10.2).
- Fungi L25.
- Yeast mitochondrial YmL41 (gene MRPL41 or MRP20).
As a signature pattern, we selected a small conserved region in the C-terminal section of these proteins, which is probably involved in rRNA-binding [2].
Last update:July 1999 / Pattern and text revised.
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References
| 1 | Authors | El Baradi T.T.A.L. Raue H.A. van de Regt C.H.F. Verbree E.C. Planta R.J. |
| Source | EMBO J. 4:210-2107(1985). |
| 2 | Authors | Raue H.A. Otaka E. Suzuki K. |
| Title | Structural comparison of 26S rRNA-binding ribosomal protein L25 from two different yeast strains and the equivalent proteins from three eubacteria and two chloroplasts. | |
| Source | J. Mol. Evol. 28:418-426(1989). | |
| PubMed ID | 2501503 |
| 3 | Authors | Fearon K. Mason T.L. |
| Title | Structure and function of MRP20 and MRP49, the nuclear genes for two proteins of the 54 S subunit of the yeast mitochondrial ribosome. | |
| Source | J. Biol. Chem. 267:5162-5170(1992). | |
| PubMed ID | 1544898 |
| 4 | Authors | Otaka E. Hashimoto T. Mizuta K. |
| Source | Protein Seq. Data Anal. 5:285-300(1993). |
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