PROSITE documentation PDOC00049Ribosomal protein L23 signature
Description
Ribosomal protein L23 is one of the proteins from the large ribosomal subunit. In Escherichia coli, L23 is known to bind a specific region on the 23S rRNA; in yeast, the corresponding protein binds to a homologous site on the 26S rRNA [1]. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [2,3,4], groups:
- Eubacterial L23.
- Algal and plant chloroplast L23.
- Archaebacterial L23.
- Mammalian L23A.
- Caenorhabditis elegans L23A (F55D10.2).
- Fungi L25.
- Yeast mitochondrial YmL41 (gene MRPL41 or MRP20).
As a signature pattern, we selected a small conserved region in the C-terminal section of these proteins, which is probably involved in rRNA-binding [2].
Last update:July 1999 / Pattern and text revised.
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References
| 1 | Authors | El Baradi T.T.A.L. Raue H.A. van de Regt C.H.F. Verbree E.C. Planta R.J. |
| Source | EMBO J. 4:210-2107(1985). |
| 2 | Authors | Raue H.A. Otaka E. Suzuki K. |
| Title | Structural comparison of 26S rRNA-binding ribosomal protein L25 from two different yeast strains and the equivalent proteins from three eubacteria and two chloroplasts. | |
| Source | J. Mol. Evol. 28:418-426(1989). | |
| PubMed ID | 2501503 |
| 3 | Authors | Fearon K. Mason T.L. |
| Title | Structure and function of MRP20 and MRP49, the nuclear genes for two proteins of the 54 S subunit of the yeast mitochondrial ribosome. | |
| Source | J. Biol. Chem. 267:5162-5170(1992). | |
| PubMed ID | 1544898 |
| 4 | Authors | Otaka E. Hashimoto T. Mizuta K. |
| Source | Protein Seq. Data Anal. 5:285-300(1993). |
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