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PROSITE documentation PDOC00049
Ribosomal protein L23 signature


Description

Ribosomal protein L23 is one of the proteins from the large ribosomal subunit. In Escherichia coli, L23 is known to bind a specific region on the 23S rRNA; in yeast, the corresponding protein binds to a homologous site on the 26S rRNA [1]. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [2,3,4], groups:

  • Eubacterial L23.
  • Algal and plant chloroplast L23.
  • Archaebacterial L23.
  • Mammalian L23A.
  • Caenorhabditis elegans L23A (F55D10.2).
  • Fungi L25.
  • Yeast mitochondrial YmL41 (gene MRPL41 or MRP20).

As a signature pattern, we selected a small conserved region in the C-terminal section of these proteins, which is probably involved in rRNA-binding [2].

Last update:

July 1999 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_L23, PS00050; Ribosomal protein L23 signature  (PATTERN)


References

1AuthorsEl Baradi T.T.A.L. Raue H.A. van de Regt C.H.F. Verbree E.C. Planta R.J.
SourceEMBO J. 4:210-2107(1985).

2AuthorsRaue H.A. Otaka E. Suzuki K.
TitleStructural comparison of 26S rRNA-binding ribosomal protein L25 from two different yeast strains and the equivalent proteins from three eubacteria and two chloroplasts.
SourceJ. Mol. Evol. 28:418-426(1989).
PubMed ID2501503

3AuthorsFearon K. Mason T.L.
TitleStructure and function of MRP20 and MRP49, the nuclear genes for two proteins of the 54 S subunit of the yeast mitochondrial ribosome.
SourceJ. Biol. Chem. 267:5162-5170(1992).
PubMed ID1544898

4AuthorsOtaka E. Hashimoto T. Mizuta K.
SourceProtein Seq. Data Anal. 5:285-300(1993).



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