PROSITE documentation PDOC00056
Ribosomal protein S18 signature


Ribosomal protein S18 is one of the proteins from the small ribosomal subunit. subunit. In Escherichia coli, S18 has been involved in aminoacyl-tRNA binding [1]. It appears to be situated at the tRNA A-site of the ribosome. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [2], groups:

  • Eubacterial S18.
  • Algal and plant chloroplast S18.
  • Cyanelle S18.

As a signature pattern, we selected a conserved region in the central section of the protein. This region contains two basic residues which may be involved in RNA-binding.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_S18, PS00057; Ribosomal protein S18 signature  (PATTERN)


1AuthorsMcDougall J. Choli T. Kruft V. Kapp U. Wittmann-Liebold B.
TitleThe complete amino acid sequence of ribosomal protein S18 from the moderate thermophile Bacillus stearothermophilus.
SourceFEBS Lett. 245:253-260(1989).
PubMed ID2647521

2AuthorsOtaka E. Hashimoto T. Mizuta K.
SourceProtein Seq. Data Anal. 5:285-300(1993).

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