Copper type II, ascorbate-dependent monooxygenases  are a class of enzymes
that requires copper as a cofactor and which uses ascorbate as an electron
donor. The enzymes which belong to this category are:
Dopamine-β-monooxygenase (EC 126.96.36.199) (DBH) , which catalyzes the
conversion of dopamine to the neurotransmitter norepinephrine.
Peptidyl-glycine α-amidating monooxygenase (EC 188.8.131.52) (PAM), which
catalyzes the conversion of the carboxy-terminal glycine of many active
peptides and hormones to an amide group.
There are a few regions of sequence similarities between these two enzymes,
two of these regions contain clusters of conserved histidine residues which
are most probably involved in binding copper. We selected these two regions
as signature patterns.
May 2004 / Text revised.
PROSITE methods (with tools and information) covered by this documentation:
Southan C. Kruse L.I.
Sequence similarity between dopamine beta-hydroxylase and peptide alpha-amidating enzyme: evidence for a conserved catalytic domain.
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