PROSITE entry PS00085

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00085
Entry name [info]	CU2_MONOOXYGENASE_2
Accession [info]	PS00085
Entry type [info]	PATTERN
Date [info]	01-APR-1990 CREATED; 01-APR-1990 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00080

Name and characterization of the entry

Description [info]	Copper type II, ascorbate-dependent monooxygenases signature 2.
Pattern [info]	H-x-F-x(4)-H-T-H-x(2)-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	13 in 13 different sequences
Number of true positive hits	13 in 13 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	14
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	48.15 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Site [info]	copper at position 1
Site [info]	copper at position 5
Site [info]	copper at position 7
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

13 sequences

AMDA_XENLA  (P08478), AMDB_XENLA  (P12890), AMDL_CAEEL  (P83388),

AMD_BOVIN   (P10731), AMD_HUMAN   (P19021), AMD_MOUSE   (P97467), 
AMD_RAT (P14925), DOPO_BOVIN  (P15101), DOPO_HORSE  (Q9XTA0), 
DOPO_HUMAN  (P09172), DOPO_MOUSE  (Q64237), PHM_CAEEL   (Q95XM2), 
PHM_DROME   (O01404)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

14 sequences

DOPO_CANLF  (Q68CI2), DOPO_RAT(Q05754), MOX11_DROME (Q9VUY0),

MOX12_DROME (Q6NP60), MOXD1_CHICK (Q98ST7), MOXD1_DANRE (Q5TZ24), 
MOXD1_HUMAN (Q6UVY6), MOXD1_MOUSE (Q9CXI3), MOXD2_DANRE (Q08CS6), 
MOXD2_HUMAN (A6NHM9), MOXD2_MOUSE (Q7TT41), TBH1_CAEBR  (Q61P40), 
TBH1_CAEEL  (Q9XTQ6), TBH1_DROME  (Q86B61)

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PDB
[Detailed view]

33 PDB

1OPM; 1PHM; 1SDW; 1YI9; 1YIP; 1YJK; 1YJL; 3MIB; 3MIC; 3MID; 3MIE; 3MIF; 3MIG; 3MIH; 3MLJ; 3MLK; 3MLL; 3PHM; 4E4Z; 4ZEL; 5WJA; 5WKW; 5WM0; 6ALA; 6ALV; 6AMP; 6AN3; 6AO6; 6AY0; 6NCK; 8DSJ; 8DSL; 8DSN
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