Manganese superoxide dismutase (EC 220.127.116.11) (SODM)  is one of the three
forms of an enzyme that catalyzes the dismutation of superoxide radicals. The
four ligands of the manganese atom are conserved in all the known SODM
sequences. These metal ligands are also conserved in the related iron form of
superoxide dismutases [2,3]. We selected, as a signature, a short conserved
region which includes two of the four ligands: an aspartate and a histidine.
December 2004 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
Bannister J.V. Bannister W.H. Rotilio G.
Aspects of the structure, function, and applications of superoxide dismutase.
PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
or see: prosite_license.html.