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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE documentation PDOC00084
Ribonucleotide reductase large subunit signature


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PURL: https://purl.expasy.org/prosite/documentation/PDOC00084

Description

Ribonucleotide reductase (EC 1.17.4.1) [1,2] catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. Ribonucleotide reductase is an oligomeric enzyme composed of a large subunit (700 to 1000 residues) and a small subunit (300 to 400 residues). There are regions of similarities in the sequence of the large chain from prokaryotes, eukaryotes and viruses. We have selected one of these regions as a signature pattern.

Last update:

December 2001 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBORED_LARGE, PS00089; Ribonucleotide reductase large subunit signature  (PATTERN)


References

1AuthorsNillson O. Lundqvist T. Hahne S. Sjoberg B.-M.
SourceBiochem. Soc. Trans. 16:91-94(1988).

2AuthorsReichard P.
TitleFrom RNA to DNA, why so many ribonucleotide reductases?
SourceScience 260:1773-1777(1993).
PubMed ID8511586



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