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PROSITE documentation PDOC00177 |
There are multiple types of iron-sulfur clusters which are grouped into three main categories based on their atomic content: [2Fe-2S], [3Fe-4S], [4Fe-4S] (see <PDOC00176>), and other hybrid or mixed metal types. Two general types of [2Fe-2S] clusters are known and they differ in their coordinating residues. The ferredoxin-type [2Fe-2S] clusters are coordinated to the protein by four cysteine residues (see <PDOC00175>). The Rieske-type [2Fe-2S] cluster is coordinated to its protein by two cysteine residues and two histidine residues [1,2].
The structure of several Rieske domains has been solved (see for example <PDB:1RIE>) [3]. It contains three layers of antiparallel β sheets forming two β sandwiches. Both β sandwiches share the central sheet 2. The metal-binding site is at the top of the β sandwich formed by the sheets 2 and 3. The Fe1 iron of the Rieske cluster is coordinated by two cysteines while the other iron Fe2 is coordinated by two histidines. Two inorganic sulfide ions bridge the two iron ions forming a flat, rhombic cluster.
Rieske-type iron-sulfur clusters are common to electron transfer chains of mitochondria and chloroplast and to non-heme iron oxygenase systems:
The profile we developed covers the whole Rieske domain.
Last update:March 2007 / Text revised; profiles added; patterns deleted.
Note:The Rieske profile is in competition with a profile of a related domain, i.e. nirD Rieske-like domain (see <PDOC51300>).
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Ferraro D.J. Gakhar L. Ramaswamy S. |
Title | Rieske business: structure-function of Rieske non-heme oxygenases. | |
Source | Biochem. Biophys. Res. Commun. 338:175-190(2005). | |
PubMed ID | 16168954 | |
DOI | 10.1016/j.bbrc.2005.08.222 |
2 | Authors | Schneider D. Schmidt C.L. |
Title | Multiple Rieske proteins in prokaryotes: where and why? | |
Source | Biochim. Biophys. Acta 1710:1-12(2005). | |
PubMed ID | 16271700 | |
DOI | 10.1016/j.bbabio.2005.09.003 |
3 | Authors | Iwata S. Saynovits M. Link T.A. Michel H. |
Title | Structure of a water soluble fragment of the 'Rieske' iron-sulfur protein of the bovine heart mitochondrial cytochrome bc1 complex determined by MAD phasing at 1.5 A resolution. | |
Source | Structure 4:567-579(1996). | |
PubMed ID | 8736555 |