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PROSITE documentation PDOC51300

NADH-nitrite reductase subunit D family profile





Description

In Proteobacteria and Actinobacteria the main nitrite reductase activity is contributed by the NADH-dependent nitrite reductase, which detoxifies the nitrite formed as the product of nitrate reduction. The NADH-nitrite reductase operon consists of 4 genes: nirB, nirD, nirC and cysG. The enzyme is formed by the two subunits nirB and nirD. NirC is a nitrite transporter and cysG is required for the synthesis of siroheme, a cofactor of the nirB subunit [1,2].

NirD displays some sequence similarities with the 2Fe-2S Rieske domain (see <PDOC00177>), but it does not contain the essential residues for the coordination of the iron sulfur [3].

The profile we developed covers the whole conserved region.

Last update:

March 2007 / First entry.

Note:

The nirD profile is in competition with a profile of a related domain, i.e. Rieske domain (see <PDOC51300>).

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Technical section

PROSITE method (with tools and information) covered by this documentation:

NIRD, PS51300; NADH-nitrite reductase subunit D family profile  (MATRIX)


References

1AuthorsCole J.
TitleNitrate reduction to ammonia by enteric bacteria: redundancy, or a strategy for survival during oxygen starvation?
SourceFEMS Microbiol. Lett. 136:1-11(1996).
PubMed ID8919448

2AuthorsPeakman T. Crouzet J. Mayaux J.F. Busby S. Mohan S. Harborne N. Wootton J. Nicolson R. Cole J.
TitleNucleotide sequence, organisation and structural analysis of the products of genes in the nirB-cysG region of the Escherichia coli K-12 chromosome.
SourceEur. J. Biochem. 191:315-323(1990).
PubMed ID2200672

3AuthorsHulo N.
SourceUnpublished observations (2007).



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