PROSITE documentation PDOC51300NADH-nitrite reductase subunit D family profile
In Proteobacteria and Actinobacteria the main nitrite reductase activity is contributed by the NADH-dependent nitrite reductase, which detoxifies the nitrite formed as the product of nitrate reduction. The NADH-nitrite reductase operon consists of 4 genes: nirB, nirD, nirC and cysG. The enzyme is formed by the two subunits nirB and nirD. NirC is a nitrite transporter and cysG is required for the synthesis of siroheme, a cofactor of the nirB subunit [1,2].
NirD displays some sequence similarities with the 2Fe-2S Rieske domain (see <PDOC00177>), but it does not contain the essential residues for the coordination of the iron sulfur [3].
The profile we developed covers the whole conserved region.
Last update:March 2007 / First entry.
Note:The nirD profile is in competition with a profile of a related domain, i.e. Rieske domain (see <PDOC51300>).
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Cole J. |
| Title | Nitrate reduction to ammonia by enteric bacteria: redundancy, or a strategy for survival during oxygen starvation? | |
| Source | FEMS Microbiol. Lett. 136:1-11(1996). | |
| PubMed ID | 8919448 |
| 2 | Authors | Peakman T. Crouzet J. Mayaux J.F. Busby S. Mohan S. Harborne N. Wootton J. Nicolson R. Cole J. |
| Title | Nucleotide sequence, organisation and structural analysis of the products of genes in the nirB-cysG region of the Escherichia coli K-12 chromosome. | |
| Source | Eur. J. Biochem. 191:315-323(1990). | |
| PubMed ID | 2200672 |
| 3 | Authors | Hulo N. |
| Source | Unpublished observations (2007). |
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