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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE documentation PDOC00179
Rubredoxin signature


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PURL: https://purl.expasy.org/prosite/documentation/PDOC00179

Description

Rubredoxins [1] are small electron-transfer prokaryotic proteins. They contain an iron atom which is ligated by four cysteine residues. Rubredoxins are, in some cases, functionally interchangeable with ferredoxins. As a pattern for these proteins we have selected a conserved region that includes two of the cysteine residues that bind the iron atom.

Note:

In Pseudomonas oleovorans rubredoxin 2 (gene alkG) [2], this pattern is found twice because alkG has two rubredoxin domains.

Note:

Rubrerythrin [3], a protein with inorganic pyrophosphatase activity from Desulfovibrio vulgaris possesses a C-terminal rubredoxin-like domain. But this domain is too divergent to be detected by the above pattern.

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

RUBREDOXIN, PS00202; Rubredoxin signature  (PATTERN)


References

1AuthorsBerg J.M. Holm R.H.
Source(In) Iron-sulfur proteins, Spiro T.G., Ed., pp1-66, Wiley, New-York, (1982).

2AuthorsKok M. Oldenhuis R. der Linden M.P.G. Meulenberg C.H.C. Kingma J.
TitleWitholt B The Pseudomonas oleovorans alkBAC operon encodes two structurally related rubredoxins and an aldehyde dehydrogenase.
SourceJ. Biol. Chem. 264:5442-5451(1989).
PubMed ID2647719

3Authorsvan Beeumen J.J. van Driessche G. Liu M.-Y. Le Gall J.
TitleThe primary structure of rubrerythrin, a protein with inorganic pyrophosphatase activity from Desulfovibrio vulgaris. Comparison with hemerythrin and rubredoxin.
SourceJ. Biol. Chem. 266:20645-20653(1991).
PubMed ID1657933



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