PROSITE documentation PDOC00191
Amino acid permeases signature


Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [1,2,3]. These proteins are:

  • Yeast general amino acid permeases (genes GAP1, AGP2 and AGP3).
  • Yeast basic amino acid permease (gene ALP1).
  • Yeast Leu/Val/Ile permease (gene BAP2).
  • Yeast arginine permease (gene CAN1).
  • Yeast dicarboxylic amino acid permease (gene DIP5).
  • Yeast asparagine/glutamine permease (gene AGP1).
  • Yeast glutamine permease (gene GNP1).
  • Yeast histidine permease (gene HIP1).
  • Yeast lysine permease (gene LYP1).
  • Yeast proline permease (gene PUT4).
  • Yeast valine and tyrosine permease (gene VAL1/TAT1).
  • Yeast tryptophan permease (gene TAT2/SCM2).
  • Yeast choline transport protein (gene HNM1/CTR1).
  • Yeast GABA permease (gene UGA4).
  • Yeast hypothetical protein YKL174c.
  • Fission yeast protein isp5.
  • Fission yeast hypothetical protein SpAC8A4.11
  • Fission yeast hypothetical protein SpAC11D3.08c.
  • Emericella nidulans proline transport protein (gene prnB).
  • Trichoderma harzianum amino acid permease INDA1.
  • Salmonella typhimurium L-asparagine permease (gene ansP).
  • Escherichia coli aromatic amino acid transport protein (gene aroP).
  • Escherichia coli D-serine/D-alanine/glycine transporter (gene cycA).
  • Escherichia coli GABA permease (gene gabP).
  • Escherichia coli lysine-specific permease (gene lysP).
  • Escherichia coli phenylalanine-specific permease (gene pheP).
  • Salmonella typhimurium proline-specific permease (gene proY).
  • Escherichia coli and Klebsiella pneumoniae hypothetical protein yeeF.
  • Escherichia coli and Salmonella typhimurium hypothetical protein yifK.
  • Bacillus subtilis permeases rocC and rocE which probably transports arginine or ornithine.

These proteins seem to contain up to 12 transmembrane segments. As a signature for this family of proteins we selected the best conserved region which is located in the second transmembrane segment.

Last update:

July 1999 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

AMINO_ACID_PERMEASE_1, PS00218; Amino acid permeases signature  (PATTERN)


1AuthorsWeber E. Chevallier M.R. Jund R.
TitleEvolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae.
SourceJ. Mol. Evol. 27:341-350(1988).
PubMed ID3146645

2AuthorsVandenbol M. Jauniaux J.-C. Grenson M.
TitleNucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.
SourceGene 83:153-159(1989).
PubMed ID2687114

3AuthorsReizer J. Finley K. Kakuda D. McLeod C.L. Reizer A. Saier M.H. Jr.
TitleMammalian integral membrane receptors are homologous to facilitators and antiporters of yeast, fungi, and eubacteria.
SourceProtein Sci. 2:20-30(1993).
PubMed ID8382989

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)