PROSITE documentation PDOC00191Amino acid permeases signature
Description
Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [1,2,3]. These proteins are:
- Yeast general amino acid permeases (genes GAP1, AGP2 and AGP3).
- Yeast basic amino acid permease (gene ALP1).
- Yeast Leu/Val/Ile permease (gene BAP2).
- Yeast arginine permease (gene CAN1).
- Yeast dicarboxylic amino acid permease (gene DIP5).
- Yeast asparagine/glutamine permease (gene AGP1).
- Yeast glutamine permease (gene GNP1).
- Yeast histidine permease (gene HIP1).
- Yeast lysine permease (gene LYP1).
- Yeast proline permease (gene PUT4).
- Yeast valine and tyrosine permease (gene VAL1/TAT1).
- Yeast tryptophan permease (gene TAT2/SCM2).
- Yeast choline transport protein (gene HNM1/CTR1).
- Yeast GABA permease (gene UGA4).
- Yeast hypothetical protein YKL174c.
- Fission yeast protein isp5.
- Fission yeast hypothetical protein SpAC8A4.11
- Fission yeast hypothetical protein SpAC11D3.08c.
- Emericella nidulans proline transport protein (gene prnB).
- Trichoderma harzianum amino acid permease INDA1.
- Salmonella typhimurium L-asparagine permease (gene ansP).
- Escherichia coli aromatic amino acid transport protein (gene aroP).
- Escherichia coli D-serine/D-alanine/glycine transporter (gene cycA).
- Escherichia coli GABA permease (gene gabP).
- Escherichia coli lysine-specific permease (gene lysP).
- Escherichia coli phenylalanine-specific permease (gene pheP).
- Salmonella typhimurium proline-specific permease (gene proY).
- Escherichia coli and Klebsiella pneumoniae hypothetical protein yeeF.
- Escherichia coli and Salmonella typhimurium hypothetical protein yifK.
- Bacillus subtilis permeases rocC and rocE which probably transports arginine or ornithine.
These proteins seem to contain up to 12 transmembrane segments. As a signature for this family of proteins we selected the best conserved region which is located in the second transmembrane segment.
Last update:July 1999 / Pattern and text revised.
-------------------------------------------------------------------------------
Technical section
PROSITE method (with tools and information) covered by this documentation:
References
1 | Authors | Weber E. Chevallier M.R. Jund R. |
Title | Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae. | |
Source | J. Mol. Evol. 27:341-350(1988). | |
PubMed ID | 3146645 |
2 | Authors | Vandenbol M. Jauniaux J.-C. Grenson M. |
Title | Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases. | |
Source | Gene 83:153-159(1989). | |
PubMed ID | 2687114 |
3 | Authors | Reizer J. Finley K. Kakuda D. McLeod C.L. Reizer A. Saier M.H. Jr. |
Title | Mammalian integral membrane receptors are homologous to facilitators and antiporters of yeast, fungi, and eubacteria. | |
Source | Protein Sci. 2:20-30(1993). | |
PubMed ID | 8382989 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
Miscellaneous
View entry in original PROSITE document format
View entry in raw text format (no links)