PROSITE documentation PDOC00203
F-actin capping protein beta subunit signature


The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike gelsolin and severin this protein does not sever actin filaments. The F-actin capping protein is a heterodimer composed of two unrelated subunits: α and β.

The β subunit is a protein of about 280 amino acid residues whose sequence is well conserved in eukaryotic species [1]. As a signature pattern we chose a conserved hexapeptide in the N-terminal section of the β subunit.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

F_ACTIN_CAPPING_BETA, PS00231; F-actin capping protein beta subunit signature  (PATTERN)


1AuthorsAmatruda J.F. Cannon J.F. Tatchell K. Hug C. Cooper J.A.
TitleDisruption of the actin cytoskeleton in yeast capping protein mutants.
SourceNature 344:352-354(1990).
PubMed ID2179733

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