PROSITE documentation PDOC00203F-actin capping protein beta subunit signature
The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike gelsolin and severin this protein does not sever actin filaments. The F-actin capping protein is a heterodimer composed of two unrelated subunits: α and β.
The β subunit is a protein of about 280 amino acid residues whose sequence is well conserved in eukaryotic species [1]. As a signature pattern we chose a conserved hexapeptide in the N-terminal section of the β subunit.
Last update:December 2004 / Pattern and text revised.
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| 1 | Authors | Amatruda J.F. Cannon J.F. Tatchell K. Hug C. Cooper J.A. |
| Title | Disruption of the actin cytoskeleton in yeast capping protein mutants. | |
| Source | Nature 344:352-354(1990). | |
| PubMed ID | 2179733 |
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