PROSITE documentation PDOC00229
Adipokinetic hormone family signature


Adipokinetic hormones (AKH) [1,2] are small active peptides produced by some insect species. They bring on the release of diglycerides from the fat body and then stimulate the flight muscles to use them as an energy source. Other types of active peptides structurally related to AKH are:

  • Hypertrehalosaemic factors (HTF), which are neuropeptides that elevate the level of trehalose in the hemolymph of some insects.
  • Red pigment concentrating hormone (RPCH), a peptide that stimulates pigment concentration in prawn and crab erythrophores.

These peptides are eight to ten amino acid residues long. The signature pattern to detect them is based on the sequence of the first eight residues, which are common to all these peptides.

Last update:

November 1997 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

AKH, PS00256; Adipokinetic hormone family signature  (PATTERN)


1AuthorsSchaffer M.H. Noyes B.E. Slaughter C.A. Thorne G.C. Gaskell S.J.
TitleThe fruitfly Drosophila melanogaster contains a novel charged adipokinetic-hormone-family peptide.
SourceBiochem. J. 269:315-320(1990).
PubMed ID2117437

2AuthorsGade G. Hilbich C. Beyreuther K. Rinehart K.L. Jr.
TitleSequence analyses of two neuropeptides of the AKH/RPCH-family from the lubber grasshopper, Romalea microptera.
SourcePeptides 9:681-688(1988).
PubMed ID3226948

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