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PROSITE documentation PDOC00258 |
The squash family of serine protease inhibitor [1] is one of the numerous families of serine proteinase inhibitors. The proteins belonging to this family are found in the seeds of cucurbitaceae plants (cucumber, squash, bitter gourd, etc.). The basic structure of such a type of inhibitor is shown in the following schematic representation:
+----------------+ | | *****************|** xxCx#xxxxCxxxxxCxxxCxCxxxxxCx | | | | | +-----|-----+ +-----------+ <--------30 residues-------->
'C': conserved cysteine involved in a disulfide bond. '#': active site residue. '*': position of the pattern.
The pattern we have used to detect this family of proteins spans the major part of the sequence and includes five of the six cysteines involved in disulfide bonds.
Last update:May 2004 / Text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Otlewski J. |
Title | The squash inhibitor family of serine proteinases. | |
Source | Biol. Chem. Hoppe-Seyler 371:23-28(1990). | |
PubMed ID | 2205236 |