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PROSITE documentation PDOC00259 |
Inhibitors of cysteine proteases [1,2,3], which are found in the tissues and body fluids of animals, in the larva of the worm Onchocerca volvulus [4], as well as in plants, can be grouped into three distinct but related families:
In all these inhibitors, there is a conserved region of five residues which has been proposed to be important for the binding to the cysteine proteases. Our pattern starts one residue before this conserved region.
Note:This pattern is always twice in kininogens.
Note:Members of the fetuin family (see <PDOC00966>) contain two copies of a cystatin-like domain.
Expert(s) to contact by email: Last update:April 2006 / Pattern revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Barrett A.J. |
Source | Trends Biochem. Sci. 12:193-196(1987). |
2 | Authors | Rawlings N.D. Barrett A.J. |
Title | Evolution of proteins of the cystatin superfamily. | |
Source | J. Mol. Evol. 30:60-71(1990). | |
PubMed ID | 2107324 |
3 | Authors | Turk V. Bode W. |
Title | The cystatins: protein inhibitors of cysteine proteinases. | |
Source | FEBS Lett. 285:213-219(1991). | |
PubMed ID | 1855589 |
4 | Authors | Lustigman S. Brotman B. Huima T. Prince A.M. |
Title | Characterization of an Onchocerca volvulus cDNA clone encoding a genus specific antigen present in infective larvae and adult worms. | |
Source | Mol. Biochem. Parasitol. 45:65-75(1991). | |
PubMed ID | 2052041 |