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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS00287


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PURL: https://purl.expasy.org/prosite/signature/PS00287

Direct ScanProsite submission
General information about the entry

Entry name [info] CYSTATIN
Accession [info] PS00287
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00259

Name and characterization of the entry

Description [info] Cysteine proteases inhibitors signature.
Pattern [info] 
[GSTEQKRV]-Q-[LIVT]-[VAF]-[SAGQ]-G-{DG}-[LIVMNK]-{TK}-x-[LIVMFY]-{S}-
[LIVMFYA]-[DENQKRHSIV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 131 in 123 different sequences
Number of true positive hits 113 in 105 different sequences
Number of 'unknown' hits 0
Number of false positive hits 18 in 18 different sequences
Number of false negative sequences 47
Number of 'partial' sequences 5
Precision (true positives / (true positives + false positives)) 86.26 %
Recall (true positives / (true positives + false negatives)) 70.62 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 105 sequences 

CPI1_PIG(P35479), CPI2_BRUMA  (A0A0K0IP23), CSTD_MOUSE  (Q9JM84), 

CYS17_PLARH (A0A6B9L8T7), CYS1_ORNMO  (Q6QZV5), CYS2_ORNMO  (Q6QD55), 
CYT11_ORYSJ (Q6K309), CYT12_ORYSJ (Q0JNR2), CYT1_ARATH  (Q945Q1), 
CYT1_CROAD  (J3RYX9), CYT1_HORVU  (Q9LEI7), CYT1_MAIZE  (P31726), 
CYT1_MOUSE  (P35175), CYT1_ORYSJ  (P09229), CYT2_ARATH  (Q8L5T9), 
CYT2_CROAD  (J3SE80), CYT2_MOUSE  (P35174), CYT2_ORYSJ  (P20907), 
CYT3_ARATH  (Q41906), CYT3_MOUSE  (P35173), CYT6_ARATH  (Q8H0X6), 
CYT6_ORYSJ  (Q10Q46), CYT7_ARATH  (Q8LC76), CYT7_ORYSJ  (Q10Q47), 
CYT8_ORYSJ  (Q10J94), CYTA1_DICDI (Q65YR8), CYTA1_PIG   (Q28988), 
CYTA5_PIG   (Q28986), CYTA8_PIG   (Q28987), CYTA_BOVIN  (P80416), 
CYTA_FELCA  (Q8WNR9), CYTA_HELAN  (Q10992), CYTA_HUMAN  (P01040), 
CYTA_MOUSE  (P56567), CYTA_RAT(P01039), CYTA_SARPE  (P31727), 
CYTB_BOVIN  (P25417), CYTB_GORGO  (Q76LA0), CYTB_HELAN  (Q10993), 
CYTB_HUMAN  (P04080), CYTB_MACFU  (Q862Z5), CYTB_MOUSE  (Q62426), 
CYTB_OPLFA  (J7FQE8), CYTB_PANPA  (P60575), CYTB_PANTR  (Q8I030), 
CYTB_PIG(Q29290), CYTB_PONPY  (P60576), CYTB_RAT(P01041), 
CYTB_SHEEP  (Q10994), CYTC_BOVIN  (P01035), CYTC_HUMAN  (P01034), 
CYTC_MACMU  (O19092), CYTC_MOUSE  (P21460), CYTC_PAROL  (B2Z450), 
CYTC_RAT(P14841), CYTC_SAISC  (O19093), CYTD_HUMAN  (P28325), 
CYTI_VIGUN  (Q06445), CYTL2_IXOPE (A0A5C1J0Z8), CYTL2_IXOSC (B7PKZ1), 
CYTLG_IXOSC (B7PKZ2), CYTL_DROME  (P23779), CYTL_IXOPE  (A0A224AHH8), 
CYTL_IXOSC  (Q8MVB6), CYTL_TACTR  (Q7M429), CYTM_HUMAN  (Q15828), 
CYTM_SOLTU  (P37842), CYTN_HUMAN  (P01037), CYTS_HUMAN  (P01036), 
CYTS_RAT(P19313), CYTT_HUMAN  (P09228), CYTX_BOVIN  (P35478), 
CYTX_ONCVO  (P22085), CYT_BITAR   (P08935), CYT_BITGA   (Q6T6T4), 
CYT_CHICK   (P01038), CYT_CHIGU   (B1P1J3), CYT_COTJA   (P81061), 
CYT_CRYNI   (E3P6P1), CYT_CYPCA   (P35481), CYT_MICIK   (E3P6P3), 
CYT_NAJKA   (E3P6P4), CYT_NOTSC   (E3P6P2), CYT_ONCKE   (Q98967), 
CYT_ONCMY   (Q91195), CYT_OXYMI   (E3P6N5), CYT_OXYSC   (E3P6N6), 
CYT_PSEAU   (E3P6N8), CYT_PSEPO   (E3P6N7), CYT_PSETE   (E3P6N4), 
CYT_SOLTU   (Q03196), EPI2B_PHYIN (A1L017), EPI2B_PHYIT (D0NBV3), 
EPIC1_PHYIN (A1L015), EPIC1_PHYIT (D0NBV1), EPIC4_PHYIN (A1L019), 
EPIC4_PHYIT (D0MSS2), KNG1_BOVIN  (P01044), KNG1_HUMAN  (P01042), 
KNG1_MOUSE  (O08677), KNG1_RAT(P08934), KNG2_BOVIN  (P01045), 
KNT1_RAT(P01048), KNT2_RAT(P08932), T71A_HADIN  (P0DXA0)
» more

UniProtKB/Swiss-Prot
False negative sequences		 47 sequences 

22P1_RAT(P22282), 22P2_RAT(P22283), CPI1_BRUMA  (P90698), 

CPI1_CAEEL  (G5EDZ9), CPI2_CAEEL  (G5ECM9), CST11_HUMAN (Q9H112), 
CST11_MOUSE (Q9D269), CST11_RAT   (Q8K5A3), CST12_MOUSE (Q9DAN8), 
CST12_RAT   (Q8VII2), CST13_MOUSE (Q80ZN5), CST15_BOVIN (Q2NKZ5), 
CST16_BOVIN (Q32KQ9), CST8_HUMAN  (O60676), CST8_MOUSE  (P32766), 
CST8_RAT(O88969), CST9L_HUMAN (Q9H4G1), CST9P_HUMAN (Q5W188), 
CST9_BOVIN  (Q29RH0), CST9_HUMAN  (Q5W186), CST9_MOUSE  (Q9Z0H6), 
CSTD1_MOUSE (Q8VII3), CSTD1_RAT   (Q8VIH8), CSTL1_HUMAN (Q9H114), 
CSTL1_MOUSE (Q80Y72), CYT10_ORYSI (A2XS65), CYT10_ORYSJ (P0C579), 
CYT1_ACTCC  (P86472), CYT1_ACTDE  (Q6TPK4), CYT3_ORYSJ  (Q6I570), 
CYT4_ARATH  (Q84WT8), CYT4_ORYSJ  (Q5N806), CYT5_ARATH  (Q41916), 
CYT5_ORYSJ  (Q0JGM8), CYT9_ORYSJ  (Q10Q48), CYTA2_DICDI (Q65YR7), 
CYTA3_DICDI (Q5R1U3), CYTB_PAROL  (B2Z449), CYTC_RABIT  (O97862), 
CYTF_HUMAN  (O76096), CYTF_MOUSE  (O89098), CYT_AUSSU   (E3P6N3), 
CYT_NAJAT   (P81714), HRG_HUMAN   (P04196), HRG_MOUSE   (Q9ESB3), 
HRG_RABIT   (Q28640), HRG_RAT (Q99PS8)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 5 sequences 

CPI2_PIG(P80736), CYT1_CAPHI  (P84911), CYT2_CAPHI  (P84910), 

CYT3_WISFL  (P19864), CYT_SOYBN   (P25973)
» more

UniProtKB/Swiss-Prot
False positive sequences		 18 sequences 

ABCB4_DICDI (Q54W24), ACT_BACMT   (Q8KP10), ADPP_BACSU  (P54570), 

ATPE_ALCBS  (Q0VKX5), HEM1_CAMC5  (A7GYU7), KGUA_BACFN  (Q5L9N9), 
KGUA_BACFR  (Q64PY1), MRAY_ENTFA  (O07107), OADC_ECTM1  (A4XQ41), 
PP4R2_MOUSE (Q0VGB7), SASA_PROMP  (Q7V113), SIP5_COCIM  (Q1DZ34), 
SPXH_OCEIH  (Q8ERT3), SYM_METM5   (A4FZL1), SYM_METM7   (A6VIW5), 
SYM_METMP   (Q6M0E5), TICRR_DANRE (Q6DRL4), TOP1_MYCS2  (A0R5D9)
» more

PDB
[Detailed view]		 42 PDB

pdb_00001a67; pdb_00001a90; pdb_00001cew; pdb_00001cyu; pdb_00001cyv; pdb_00001dvc; pdb_00001dvd; pdb_00001eqk; pdb_00001g96; pdb_00001gd3; pdb_00001gd4; pdb_00001n9j; pdb_00001nb3; pdb_00001nb5; pdb_00001r4c; pdb_00001rn7; pdb_00001roa; pdb_00001stf; pdb_00001tij; pdb_00001yvb; pdb_00002oct; pdb_00003gax; pdb_00003k9m; pdb_00003kfq; pdb_00003kse; pdb_00003l0r; pdb_00003lh4; pdb_00003mwz; pdb_00003ps8; pdb_00003qrd; pdb_00004lzi; pdb_00004n6l; pdb_00004n6m; pdb_00004n6n; pdb_00004n6o; pdb_00004n6v; pdb_00004tx4; pdb_00004zm8; pdb_00006fk0; pdb_00008gt0; pdb_00008gt7; pdb_00008v57
» more