PROSITE entry PS00287
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General information about the entry
| PURL [info] | https://purl.expasy.org/prosite/signature/PS00287 |
| Entry name [info] | CYSTATIN |
| Accession [info] | PS00287 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00259 |
Name and characterization of the entry
| Description [info] | Cysteine proteases inhibitors signature. |
| Pattern [info] |
[GSTEQKRV]-Q-[LIVT]-[VAF]-[SAGQ]-G-{DG}-[LIVMNK]-{TK}-x-[LIVMFY]-{S}-
[LIVMFYA]-[DENQKRHSIV].
|
Numerical results [info]
| Total number of hits | 129 in 121 different sequences |
| Number of true positive hits | 111 in 103 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 18 in 18 different sequences |
| Number of false negative sequences | 47 |
| Number of 'partial' sequences | 5 |
| Precision (true positives / (true positives + false positives)) | 86.05 % |
| Recall (true positives / (true positives + false negatives)) | 70.25 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 3 |
| Version [info] | 2 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
103 sequences
CPI1_PIG(P35479), CPI2_BRUMA (A0A0K0IP23), CST10_MOUSE (Q9JM84), CYS17_PLARH (A0A6B9L8T7), CYS1_ORNMO (Q6QZV5), CYS2_ORNMO (Q6QD55), CYT11_ORYSJ (Q6K309), CYT12_ORYSJ (Q0JNR2), CYT1_ARATH (Q945Q1), CYT1_CROAD (J3RYX9), CYT1_HORVU (Q9LEI7), CYT1_MAIZE (P31726), CYT1_MOUSE (P35175), CYT1_ORYSJ (P09229), CYT2_ARATH (Q8L5T9), CYT2_CROAD (J3SE80), CYT2_MOUSE (P35174), CYT2_ORYSJ (P20907), CYT3_ARATH (Q41906), CYT3_MOUSE (P35173), CYT6_ARATH (Q8H0X6), CYT6_ORYSJ (Q10Q46), CYT7_ARATH (Q8LC76), CYT7_ORYSJ (Q10Q47), CYT8_ORYSJ (Q10J94), CYTA1_DICDI (Q65YR8), CYTA1_PIG (Q28988), CYTA5_PIG (Q28986), CYTA8_PIG (Q28987), CYTA_BOVIN (P80416), CYTA_FELCA (Q8WNR9), CYTA_HELAN (Q10992), CYTA_HUMAN (P01040), CYTA_MOUSE (P56567), CYTA_RAT(P01039), CYTA_SARPE (P31727), CYTB_BOVIN (P25417), CYTB_GORGO (Q76LA0), CYTB_HELAN (Q10993), CYTB_HUMAN (P04080), CYTB_MACFU (Q862Z5), CYTB_MOUSE (Q62426), CYTB_OPLFA (J7FQE8), CYTB_PANPA (P60575), CYTB_PANTR (Q8I030), CYTB_PIG(Q29290), CYTB_PONPY (P60576), CYTB_RAT(P01041), CYTB_SHEEP (Q10994), CYTC_BOVIN (P01035), CYTC_HUMAN (P01034), CYTC_MACMU (O19092), CYTC_MOUSE (P21460), CYTC_PAROL (B2Z450), CYTC_RAT(P14841), CYTC_SAISC (O19093), CYTD_HUMAN (P28325), CYTI_VIGUN (Q06445), CYTL2_IXOSC (B7PKZ1), CYTLG_IXOSC (B7PKZ2), CYTL_DROME (P23779), CYTL_IXOSC (Q8MVB6), CYTL_TACTR (Q7M429), CYTM_HUMAN (Q15828), CYTM_SOLTU (P37842), CYTN_HUMAN (P01037), CYTS_HUMAN (P01036), CYTS_RAT(P19313), CYTT_HUMAN (P09228), CYTX_BOVIN (P35478), CYTX_ONCVO (P22085), CYT_BITAR (P08935), CYT_BITGA (Q6T6T4), CYT_CHICK (P01038), CYT_CHIGU (B1P1J3), CYT_COTJA (P81061), CYT_CRYNI (E3P6P1), CYT_CYPCA (P35481), CYT_MICIK (E3P6P3), CYT_NAJKA (E3P6P4), CYT_NOTSC (E3P6P2), CYT_ONCKE (Q98967), CYT_ONCMY (Q91195), CYT_OXYMI (E3P6N5), CYT_OXYSC (E3P6N6), CYT_PSEAU (E3P6N8), CYT_PSEPO (E3P6N7), CYT_PSETE (E3P6N4), CYT_SOLTU (Q03196), EPI2B_PHYIN (A1L017), EPI2B_PHYIT (D0NBV3), EPIC1_PHYIN (A1L015), EPIC1_PHYIT (D0NBV1), EPIC4_PHYIN (A1L019), EPIC4_PHYIT (D0MSS2), KNG1_BOVIN (P01044), KNG1_HUMAN (P01042), KNG1_MOUSE (O08677), KNG1_RAT(P08934), KNG2_BOVIN (P01045), KNT1_RAT(P01048), KNT2_RAT(P08932), T71A_HADIN (P0DXA0)» more
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| UniProtKB/Swiss-Prot False negative sequences |
47 sequences
22P1_RAT(P22282), 22P2_RAT(P22283), CPI1_BRUMA (P90698), CPI1_CAEEL (G5EDZ9), CPI2_CAEEL (G5ECM9), CST11_HUMAN (Q9H112), CST11_MOUSE (Q9D269), CST11_RAT (Q8K5A3), CST12_MOUSE (Q9DAN8), CST12_RAT (Q8VII2), CST13_MOUSE (Q80ZN5), CST15_BOVIN (Q2NKZ5), CST16_BOVIN (Q32KQ9), CST8_HUMAN (O60676), CST8_MOUSE (P32766), CST8_RAT(O88969), CST9L_HUMAN (Q9H4G1), CST9P_HUMAN (Q5W188), CST9_BOVIN (Q29RH0), CST9_HUMAN (Q5W186), CST9_MOUSE (Q9Z0H6), CSTD1_MOUSE (Q8VII3), CSTD1_RAT (Q8VIH8), CSTL1_HUMAN (Q9H114), CSTL1_MOUSE (Q80Y72), CYT10_ORYSI (A2XS65), CYT10_ORYSJ (P0C579), CYT1_ACTCC (P86472), CYT1_ACTDE (Q6TPK4), CYT3_ORYSJ (Q6I570), CYT4_ARATH (Q84WT8), CYT4_ORYSJ (Q5N806), CYT5_ARATH (Q41916), CYT5_ORYSJ (Q0JGM8), CYT9_ORYSJ (Q10Q48), CYTA2_DICDI (Q65YR7), CYTA3_DICDI (Q5R1U3), CYTB_PAROL (B2Z449), CYTC_RABIT (O97862), CYTF_HUMAN (O76096), CYTF_MOUSE (O89098), CYT_AUSSU (E3P6N3), CYT_NAJAT (P81714), HRG_HUMAN (P04196), HRG_MOUSE (Q9ESB3), HRG_RABIT (Q28640), HRG_RAT (Q99PS8)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
5 sequences
CPI2_PIG(P80736), CYT1_CAPHI (P84911), CYT2_CAPHI (P84910), CYT3_WISFL (P19864), CYT_SOYBN (P25973)» more |
| UniProtKB/Swiss-Prot False positive sequences |
18 sequences
ABCB4_DICDI (Q54W24), ACT_BACMT (Q8KP10), ADPP_BACSU (P54570), ATPE_ALCBS (Q0VKX5), HEM1_CAMC5 (A7GYU7), KGUA_BACFN (Q5L9N9), KGUA_BACFR (Q64PY1), MRAY_ENTFA (O07107), OADC_ECTM1 (A4XQ41), PP4R2_MOUSE (Q0VGB7), SASA_PROMP (Q7V113), SIP5_COCIM (Q1DZ34), SPXH_OCEIH (Q8ERT3), SYM_METM5 (A4FZL1), SYM_METM7 (A6VIW5), SYM_METMP (Q6M0E5), TICRR_DANRE (Q6DRL4), TOP1_MYCS2 (A0R5D9)» more |
| PDB [Detailed view] |
42 PDB
1A67; 1A90; 1CEW; 1CYU; 1CYV; 1DVC; 1DVD; 1EQK; 1G96; 1GD3; 1GD4; 1N9J; 1NB3; 1NB5; 1R4C; 1RN7; 1ROA; 1STF; 1TIJ; 1YVB; 2OCT; 3GAX; 3K9M; 3KFQ; 3KSE; 3L0R; 3LH4; 3MWZ; 3PS8; 3QRD; 4LZI; 4N6L; 4N6M; 4N6N; 4N6O; 4N6V; 4TX4; 4ZM8; 6FK0; 8GT0; 8GT7; 8V57 » more |