PROSITE documentation PDOC00264
Cyclins signature


Cyclins [1,2,3] are eukaryotic proteins which play an active role in controlling nuclear cell division cycles. Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins:

  • G2/M cyclins, essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase).
  • G1/S cyclins, essential for the control of the cell cycle at the G1/S (start) transition.

In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.

A cyclin homolog has also been found in herpesvirus saimiri [4].

The best conserved region is in the central part of the cyclins' sequences, known as the 'cyclin-box', from which we have derived a 32 residue pattern.

Last update:

November 1995 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CYCLINS, PS00292; Cyclins signature  (PATTERN)


1AuthorsNurse P.
TitleUniversal control mechanism regulating onset of M-phase.
SourceNature 344:503-508(1990).
PubMed ID2138713

2AuthorsNorbury C. Nurse P.
TitleCyclins and cell cycle control.
SourceCurr. Biol. 1:23-24(1991).
PubMed ID15336197

3AuthorsLew D.J. I Reed S.
TitleA proliferation of cyclins.
SourceTrends Cell Biol. 2:77-81(1992).
PubMed ID14731948

4AuthorsNicholas J. Cameron K.R. Honess R.W.
TitleHerpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins.
SourceNature 355:362-365(1992).
PubMed ID1309943

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