A number of eukaryotic proteins are post-translationally modified by the
attachment of either a farnesyl or a geranyl-geranyl group to a cysteine
residue [1,2,3,4]. The modification occurs on cysteine residues that are three
residues away from the C-terminal extremity; the two residues that separate
this cysteine from the C-terminal residue are generally aliphatic. This Cys-Ali-Ali-X pattern is generally known as the CAAX box. Proteins known or
strongly presumed to be the target of this modification are listed below.
Ras proteins, and ras-like proteins such as Rho, Rab, Rac, Ral, and Rap.
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