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PROSITE documentation PDOC01002

G-protein gamma subunit profile


Guanine nucleotide-binding proteins (G proteins) [1] act as intermediaries in the transduction of signals generated by transmembrane receptors. G proteins consist of three subunits (α, β, and γ). The α subunit binds to and hydrolyzes GTP; the functions of the β and γ subunits are less clear but they seem to be required for the replacement of GDP by GTP as well as for membrane anchoring and receptor recognition.

The γ subunits are small proteins (from 70 to 110 residues) that are bound to the membrane via a isoprenyl group (either a farnesyl or a geranyl-geranyl) covalently linked to their C-terminus. In mammals there are at least 12 different isoforms of γ subunits.

The Caenorhabditis elegans protein egl-10, which is a regulator of G-protein signalling, contains a G-protein γ-like domain.

We have developed a profile that spans the complete length of the γ subunit.

Expert(s) to contact by email:

Pennington S.R.

Last update:

November 1997 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

G_PROTEIN_GAMMA, PS50058; G-protein gamma subunit domain profile  (MATRIX)


1AuthorsPennington S.R.
SourceProtein Prof. 2:16-315(1995).

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