PROSITE documentation PDOC01002G-protein gamma subunit profile
Guanine nucleotide-binding proteins (G proteins) [1] act as intermediaries in the transduction of signals generated by transmembrane receptors. G proteins consist of three subunits (α, β, and γ). The α subunit binds to and hydrolyzes GTP; the functions of the β and γ subunits are less clear but they seem to be required for the replacement of GDP by GTP as well as for membrane anchoring and receptor recognition.
The γ subunits are small proteins (from 70 to 110 residues) that are bound to the membrane via a isoprenyl group (either a farnesyl or a geranyl-geranyl) covalently linked to their C-terminus. In mammals there are at least 12 different isoforms of γ subunits.
The Caenorhabditis elegans protein egl-10, which is a regulator of G-protein signalling, contains a G-protein γ-like domain.
We have developed a profile that spans the complete length of the γ subunit.
Expert(s) to contact by email: Last update:November 1997 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Pennington S.R. |
| Source | Protein Prof. 2:16-315(1995). |
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