Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC01002G-protein gamma subunit profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC01002
Guanine nucleotide-binding proteins (G proteins) [1] act as intermediaries in the transduction of signals generated by transmembrane receptors. G proteins consist of three subunits (α, β, and γ). The α subunit binds to and hydrolyzes GTP; the functions of the β and γ subunits are less clear but they seem to be required for the replacement of GDP by GTP as well as for membrane anchoring and receptor recognition.
The γ subunits are small proteins (from 70 to 110 residues) that are bound to the membrane via a isoprenyl group (either a farnesyl or a geranyl-geranyl) covalently linked to their C-terminus. In mammals there are at least 12 different isoforms of γ subunits.
The Caenorhabditis elegans protein egl-10, which is a regulator of G-protein signalling, contains a G-protein γ-like domain.
We have developed a profile that spans the complete length of the γ subunit.
Expert(s) to contact by email: Last update:November 1997 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Pennington S.R. |
| Source | Protein Prof. 2:16-315(1995). |
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