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PROSITE documentation PDOC00267 |
Arrestin (or S-antigen) [1] is a protein that interacts with light-activated phosphorylated rhodopsin thereby inhibiting or 'arresting' its ability to interact with transducin. In mammals, arrestin is associated with autoimmune uveitis.
Arrestin belongs to a family of closely related proteins including:
Sequence comparison of proteins from the arrestin family shows a high level of conservation. As a signature pattern, we selected a region located in the N-terminal section that contains many charged and hydrophobic residues.
Expert(s) to contact by email: Last update:November 1997 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Wilson C.J. Applebury M.L. |
Title | Arresting G-protein coupled receptor activity. | |
Source | Curr. Biol. 3:683-686(1993). | |
PubMed ID | 15335861 |
2 | Authors | Craft C.M. Whitmore D.H. |
Title | The arrestin superfamily: cone arrestins are a fourth family. | |
Source | FEBS Lett. 362:247-255(1995). | |
PubMed ID | 7720881 |