PROSITE documentation PDOC00277Caseins alpha/beta signature
Caseins [1] are the major protein constituent of milk. Caseins can be classified into two families; the first consists of the kappa-caseins, and the second groups the α-s1, α-s2, and β-caseins. The α/β caseins are a rapidly diverging family of proteins. However two regions are conserved: a cluster of phosphorylated serine residues and the signal sequence. The signature pattern we selected for this family of proteins is based on the last eight residues of the signal sequence.
Note:α-s2 casein is known as epsilon-casein in mouse, γ-casein in rat and casein-A in guinea pig. α-s1 casein is known as α-casein in rat and rabbit and as casein-B in guinea-pig.
Last update:December 1992 / Text revised.
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| 1 | Authors | Holt C. Sawyer L. |
| Title | Primary and predicted secondary structures of the caseins in relation to their biological functions. | |
| Source | Protein Eng. 2:251-259(1988). | |
| PubMed ID | 3074304 |
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