PROSITE documentation PDOC00281
Glycophorin A signature


Glycophorin A is the major sialoglycoprotein of erythrocyte membrane [1]. Structurally, glycophorin A consists of an N-terminal extracellular domain, heavily glycosylated on serine and threonine residues, followed by a transmembrane region and a C-terminal cytoplasmic domain.

In human there are two closely related forms: glycophorin A which carries the blood group M/N antigen, and glycophorin B which carries the blood group S/s antigen.

The best conserved region of glycophorin A is the transmembrane domain and we have derived a consensus pattern from that region.

Last update:

December 1991 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

GLYCOPHORIN_A, PS00312; Glycophorin A signature  (PATTERN)


1AuthorsMurayama J.-I. Utsumi H. Hamada A.
TitleAmino acid sequence of monkey erythrocyte glycophorin MK. Its amino acid sequence has a striking homology with that of human glycophorin A.
SourceBiochim. Biophys. Acta 999:273-280(1989).
PubMed ID2605264

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