PROSITE documentation PDOC00306
HMG-I and HMG-Y DNA-binding domain (A+T-hook)


High mobility group (HMG) proteins are a family of relatively low molecular weight non-histone components in chromatin. HMG-I and HMG-Y are proteins of about 100 amino acid residues which are produced by the alternative splicing of a single gene (HMG-Y differs from HMG-I by the internal deletion of 11 amino acids). HMG-I/Y bind preferentially to the minor groove of A+T-rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3' end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to, A+T-rich regions.

DNA-binding of these proteins is effected by a 11 residues domain, called the A+T-hook [1], this domain is repeated three times in the sequence of HMG-I/Y.

Last update:

October 1993 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

HMGI_Y, PS00354; HMG-I and HMG-Y DNA-binding domain (A+T-hook)  (PATTERN)


1AuthorsReeves R. Nissen M.S.
TitleThe A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure.
SourceJ. Biol. Chem. 265:8573-8582(1990).
PubMed ID1692833

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