PROSITE entry PS00354

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00354
Entry name [info]	HMGI_Y
Accession [info]	PS00354
Entry type [info]	PATTERN
Date [info]	01-NOV-1990 CREATED; 01-OCT-1993 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00306

Name and characterization of the entry

Description [info]	HMG-I and HMG-Y DNA-binding domain (A+T-hook).
Pattern [info]	[AT]-x(1,2)-[RK](2)-[GP]-R-G-R-P-[RK]-x.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	39 in 27 different sequences
Number of true positive hits	32 in 20 different sequences
Number of 'unknown' hits	0
Number of false positive hits	7 in 7 different sequences
Number of false negative sequences	6
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	82.05 %
Recall (true positives / (true positives + false negatives))	84.21 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	3
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	20 sequences AFFL_DROER (B3NAM7), AFFL_DROGR (B4JQ42), AFFL_DROME (Q9VQI9), AFFL_DROMO (B4KFE1), AFFL_DROPS (Q29KG4), AFFL_DROVI (B4LV24), AFFL_DROWI (B4MUE1), AFFL_DROYA (B4NXA8), HMGA1_CANLF (Q6URC2), HMGA1_CRIGR (Q9QXP3), HMGA1_HUMAN (P17096), HMGA1_MOUSE (P17095), HMGA1_RAT (Q8K585), HMGA2_HUMAN (P52926), KMT2C_HUMAN (Q8NEZ4), KMT2C_MOUSE (Q8BRH4), MYNN_DANRE (Q7ZVR6), PATZ1_HUMAN (Q9HBE1), PATZ1_MOUSE (Q5NBY9), PRH_PETCR (P48786) » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	6 sequences AFFL_DROAN (B3MLB7), CHIF_DROME (Q9NK54), HMGA1_CHITE (Q23794), HMGA2_MOUSE (P52927), LI15B_CAEEL (Q27395), SFC3_SCHPO (Q9UST7) » more
UniProtKB/Swiss-Prot False positive sequences	7 sequences BRLF1_SHV21 (Q01012), CE087_XENLA (Q5XG50), HQ1_COXBU (Q45881), KMT2A_HUMAN (Q03164), KMT2A_MOUSE (P55200), SLX4_PYRO7 (A4R1T1), WHIB7_MYCS2 (A0QTT1) » more
PDB [Detailed view]	2 PDB 2EZD; 2EZE