PROSITE documentation PDOC00315
Uricase signature


Uricase (EC (urate oxidase) [1] is the peroxisomal enzyme responsible for the degradation of urate into allantoin. Some species, like primates and birds, have lost the gene for uricase and are therefore unable to degrade urate.

Uricase is a protein of 300 to 400 amino acids, its sequence is well conserved and we have used, as a signature pattern, a highly conserved region located in the central part of the sequence.

Last update:

July 1999 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

URICASE, PS00366; Uricase signature  (PATTERN)


1AuthorsMotojima K. Kanaya S. Goto S.
TitleCloning and sequence analysis of cDNA for rat liver uricase.
SourceJ. Biol. Chem. 263:16677-16681(1988).
PubMed ID3182808

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