We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00321CDP-alcohol phosphatidyltransferases signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00321
Description
A number of phosphatidyltransferases, which are all involved in phospholipid biosynthesis and that share the property of catalyzing the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond share a conserved sequence region [1,2]. These enzymes are:
- Ethanolaminephosphotransferase (EC 2.7.8.1) from yeast (gene EPT1).
- Diacylglycerol cholinephosphotransferase (EC 2.7.8.2) from yeast (gene CPT1).
- Phosphatidylglycerophosphate synthase (EC 2.7.8.5) (CDP-diacylglycerol-- glycerol-3-phosphate 3-phosphatidyltransferase) from bacteria (gene pgsA).
- Phosphatidylserine synthase (EC 2.7.8.8) (CDP-diacylglycerol--serine O- phosphatidyltransferase) from yeast (gene CHO1) and from Bacillus subtilis (gene pssA).
- Phosphatidylinositol synthase (EC 2.7.8.11) (CDP-diacylglycerol--inositol 3-phosphatidyltransferase) from yeast (gene PIS).
These enzymes are proteins of from 200 to 400 amino acid residues. The conserved region contains three aspartic acid residues and is located in the N-terminal section of the sequences.
Last update:December 2004 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Nikawa J.-I. Kodaki T. Yamashita S. |
| Title | Primary structure and disruption of the phosphatidylinositol synthase gene of Saccharomyces cerevisiae. | |
| Source | J. Biol. Chem. 262:4876-4881(1987). | |
| PubMed ID | 3031032 |
| 2 | Authors | Hjelmstad R.H. Bell R.M. |
| Title | sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Nucleotide sequence of the EPT1 gene and comparison of the CPT1 and EPT1 gene products. | |
| Source | J. Biol. Chem. 266:5094-5103(1991). | |
| PubMed ID | 1848238 |
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