PROSITE documentation PDOC00321
CDP-alcohol phosphatidyltransferases signature


A number of phosphatidyltransferases, which are all involved in phospholipid biosynthesis and that share the property of catalyzing the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond share a conserved sequence region [1,2]. These enzymes are:

  • Ethanolaminephosphotransferase (EC from yeast (gene EPT1).
  • Diacylglycerol cholinephosphotransferase (EC from yeast (gene CPT1).
  • Phosphatidylglycerophosphate synthase (EC (CDP-diacylglycerol-- glycerol-3-phosphate 3-phosphatidyltransferase) from bacteria (gene pgsA).
  • Phosphatidylserine synthase (EC (CDP-diacylglycerol--serine O- phosphatidyltransferase) from yeast (gene CHO1) and from Bacillus subtilis (gene pssA).
  • Phosphatidylinositol synthase (EC (CDP-diacylglycerol--inositol 3-phosphatidyltransferase) from yeast (gene PIS).

These enzymes are proteins of from 200 to 400 amino acid residues. The conserved region contains three aspartic acid residues and is located in the N-terminal section of the sequences.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CDP_ALCOHOL_P_TRANSF, PS00379; CDP-alcohol phosphatidyltransferases signature  (PATTERN)


1AuthorsNikawa J.-I. Kodaki T. Yamashita S.
TitlePrimary structure and disruption of the phosphatidylinositol synthase gene of Saccharomyces cerevisiae.
SourceJ. Biol. Chem. 262:4876-4881(1987).
PubMed ID3031032

2AuthorsHjelmstad R.H. Bell R.M.
Titlesn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Nucleotide sequence of the EPT1 gene and comparison of the CPT1 and EPT1 gene products.
SourceJ. Biol. Chem. 266:5094-5103(1991).
PubMed ID1848238

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