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| PROSITE documentation PDOC00321 |
CDP-alcohol phosphatidyltransferases signature
Description
A number of phosphatidyltransferases, which are all involved in phospholipid biosynthesis and that share the property of catalyzing the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond share a conserved sequence region [1,2]. These enzymes are:
- Ethanolaminephosphotransferase (EC 2.7.8.1) from yeast (gene EPT1).
- Diacylglycerol cholinephosphotransferase (EC 2.7.8.2) from yeast (gene CPT1).
- Phosphatidylglycerophosphate synthase (EC 2.7.8.5) (CDP-diacylglycerol-- glycerol-3-phosphate 3-phosphatidyltransferase) from bacteria (gene pgsA).
- Phosphatidylserine synthase (EC 2.7.8.8) (CDP-diacylglycerol--serine O- phosphatidyltransferase) from yeast (gene CHO1) and from Bacillus subtilis (gene pssA).
- Phosphatidylinositol synthase (EC 2.7.8.11) (CDP-diacylglycerol--inositol 3-phosphatidyltransferase) from yeast (gene PIS).
These enzymes are proteins of from 200 to 400 amino acid residues. The conserved region contains three aspartic acid residues and is located in the N-terminal section of the sequences.
Last update:December 2004 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Nikawa J.-I. Kodaki T. Yamashita S. |
| Title | Primary structure and disruption of the phosphatidylinositol synthase gene of Saccharomyces cerevisiae. | |
| Source | J. Biol. Chem. 262:4876-4881(1987). | |
| PubMed ID | 3031032 |
| 2 | Authors | Hjelmstad R.H. Bell R.M. |
| Title | sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Nucleotide sequence of the EPT1 gene and comparison of the CPT1 and EPT1 gene products. | |
| Source | J. Biol. Chem. 266:5094-5103(1991). | |
| PubMed ID | 1848238 |
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