PROSITE documentation PDOC00338Secretoglobin (SCGB) family profile
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Proteins of the secretoglobin (SCGB) family have the following common characteristics: secretion, small size, α-helical, and dimeric structure [1]. The secretoglobin monomere structure is composed of four α-helices, H1 to H4, that do not form a canonical four helix-bundle motif, but a 'boomerang'-shaped structure in which helices H1, H3, and H4 form the interface of a dimeric structure displaying a large oblong internal cavity (see <PDB:1UTG>). The large cavity, at the interface of the two monomers, joined together in an antiparallel manner, is able to accommodate small- to medium-sized hydrophobic ligands but its access is sealed by two intermolecular disulfide bridges involving conserved cysteines [2,3,4,5]. A schematic representation of the location of the two disulfide bonds in the antiparallel dimer is shown below:
NH2-xxCxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxCx-COOH
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COOH-xCxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxCxx-NH2
Proteins known to be belong to the secretoglobin family are listed below:
- Uteroglobin (UTG), a steroid-inducible, cytokine-like protein with anti- inflammatory and immunomodulatory properties. It seems specific to lagomorphes (rabbit, hare, and pica) [3].
- Clara cell phospholipid-binding protein (CCPBP) (also known as CC10). CCPBP is a protein expressed by non-ciliated cells of pulmonary airway surface epithelium. Its exact function is not known. Like uteroglobin, it is an inhibitor of phospholipase A2. It binds to phosphatidylcholine, phosphatidylinositol and to polychlorinated biphenyls (PCB) [4].
- Domestic cat major allergen chain 1 (fel d I-A) and chain 2 (fel d I-B), which form a heterodimeric structure. Fel DI contains an additional disulfide bridge [5].
- Human mammaglobin, a mammary-specific protein [6].
- Rat prostatic steroid-binding protein C3 [7].
The profile we developed covers the four α-helices of the SCGB monomere.
Note:This profile replaces two patterns whose specificity was inadequate.
Note:The SCGB family was formerly known as the uteroglobin/Clara cell 10-kDa (UTG/CC10) family.
Last update:April 2007 / Patterns removed, profile added and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Klug J. Beier H.M. Bernard A. Chilton B.S. Fleming T.P. Lehrer R.I. Miele L. Pattabiraman N. Singh G. |
| Title | Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report. | |
| Source | Ann. N. Y. Acad. Sci. 923:348-354(2000). | |
| PubMed ID | 11193777 |
| 2 | Authors | Callebaut I. Poupon A. Bally R. Demaret J.P. Housset D. Delettre J. Hossenlopp P. Mornon J.P. |
| Title | The uteroglobin fold. | |
| Source | Ann. N. Y. Acad. Sci. 923:90-112(2000). | |
| PubMed ID | 11193783 |
| 3 | Authors | Bally R. Delettre J. |
| Title | Structure and refinement of the oxidized P21 form of uteroglobin at 1.64 A resolution. | |
| Source | J. Mol. Biol. 206:153-170(1989). | |
| PubMed ID | 2704039 |
| 4 | Authors | Umland T.C. Swaminathan S. Singh G. Warty V. Furey W. Pletcher J. Sax M. |
| Title | Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9 A resolution. | |
| Source | Nat. Struct. Biol. 1:538-545(1994). | |
| PubMed ID | 7664082 |
| 5 | Authors | Kaiser L. Groenlund H. Sandalova T. Ljunggren H.-G. van Hage-Hamsten M. Achour A. Schneider G. |
| Title | The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family. | |
| Source | J. Biol. Chem. 278:37730-37735(2003). | |
| PubMed ID | 12851385 | |
| DOI | 10.1074/jbc.M304740200 |
| 6 | Authors | Watson M.A. Fleming T.P. |
| Title | Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer. | |
| Source | Cancer Res. 56:860-865(1996). | |
| PubMed ID | 8631025 |
| 7 | Authors | Parker M.G. White R. Hurst H. Needham M. Tilly R. |
| Title | Prostatic steroid-binding protein. Isolation and characterization of C3 genes. | |
| Source | J. Biol. Chem. 258:12-15(1983). | |
| PubMed ID | 6294095 |
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