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PROSITE documentation PDOC00338 |
Proteins of the secretoglobin (SCGB) family have the following common characteristics: secretion, small size, α-helical, and dimeric structure [1]. The secretoglobin monomere structure is composed of four α-helices, H1 to H4, that do not form a canonical four helix-bundle motif, but a 'boomerang'-shaped structure in which helices H1, H3, and H4 form the interface of a dimeric structure displaying a large oblong internal cavity (see <PDB:1UTG>). The large cavity, at the interface of the two monomers, joined together in an antiparallel manner, is able to accommodate small- to medium-sized hydrophobic ligands but its access is sealed by two intermolecular disulfide bridges involving conserved cysteines [2,3,4,5]. A schematic representation of the location of the two disulfide bonds in the antiparallel dimer is shown below:
NH2-xxCxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxCx-COOH | | COOH-xCxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxCxx-NH2
Proteins known to be belong to the secretoglobin family are listed below:
The profile we developed covers the four α-helices of the SCGB monomere.
Note:This profile replaces two patterns whose specificity was inadequate.
Note:The SCGB family was formerly known as the uteroglobin/Clara cell 10-kDa (UTG/CC10) family.
Last update:April 2007 / Patterns removed, profile added and text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Klug J. Beier H.M. Bernard A. Chilton B.S. Fleming T.P. Lehrer R.I. Miele L. Pattabiraman N. Singh G. |
Title | Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report. | |
Source | Ann. N. Y. Acad. Sci. 923:348-354(2000). | |
PubMed ID | 11193777 |
2 | Authors | Callebaut I. Poupon A. Bally R. Demaret J.P. Housset D. Delettre J. Hossenlopp P. Mornon J.P. |
Title | The uteroglobin fold. | |
Source | Ann. N. Y. Acad. Sci. 923:90-112(2000). | |
PubMed ID | 11193783 |
3 | Authors | Bally R. Delettre J. |
Title | Structure and refinement of the oxidized P21 form of uteroglobin at 1.64 A resolution. | |
Source | J. Mol. Biol. 206:153-170(1989). | |
PubMed ID | 2704039 |
4 | Authors | Umland T.C. Swaminathan S. Singh G. Warty V. Furey W. Pletcher J. Sax M. |
Title | Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9 A resolution. | |
Source | Nat. Struct. Biol. 1:538-545(1994). | |
PubMed ID | 7664082 |
5 | Authors | Kaiser L. Groenlund H. Sandalova T. Ljunggren H.-G. van Hage-Hamsten M. Achour A. Schneider G. |
Title | The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family. | |
Source | J. Biol. Chem. 278:37730-37735(2003). | |
PubMed ID | 12851385 | |
DOI | 10.1074/jbc.M304740200 |
6 | Authors | Watson M.A. Fleming T.P. |
Title | Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer. | |
Source | Cancer Res. 56:860-865(1996). | |
PubMed ID | 8631025 |
7 | Authors | Parker M.G. White R. Hurst H. Needham M. Tilly R. |
Title | Prostatic steroid-binding protein. Isolation and characterization of C3 genes. | |
Source | J. Biol. Chem. 258:12-15(1983). | |
PubMed ID | 6294095 |