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PROSITE documentation PDOC00338

Secretoglobin (SCGB) family profile





Description

Proteins of the secretoglobin (SCGB) family have the following common characteristics: secretion, small size, α-helical, and dimeric structure [1]. The secretoglobin monomere structure is composed of four α-helices, H1 to H4, that do not form a canonical four helix-bundle motif, but a 'boomerang'-shaped structure in which helices H1, H3, and H4 form the interface of a dimeric structure displaying a large oblong internal cavity (see <PDB:1UTG>). The large cavity, at the interface of the two monomers, joined together in an antiparallel manner, is able to accommodate small- to medium-sized hydrophobic ligands but its access is sealed by two intermolecular disulfide bridges involving conserved cysteines [2,3,4,5]. A schematic representation of the location of the two disulfide bonds in the antiparallel dimer is shown below:

 NH2-xxCxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxCx-COOH
       |                                                              |
 COOH-xCxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxCxx-NH2

Proteins known to be belong to the secretoglobin family are listed below:

  • Uteroglobin (UTG), a steroid-inducible, cytokine-like protein with anti- inflammatory and immunomodulatory properties. It seems specific to lagomorphes (rabbit, hare, and pica) [3].
  • Clara cell phospholipid-binding protein (CCPBP) (also known as CC10). CCPBP is a protein expressed by non-ciliated cells of pulmonary airway surface epithelium. Its exact function is not known. Like uteroglobin, it is an inhibitor of phospholipase A2. It binds to phosphatidylcholine, phosphatidylinositol and to polychlorinated biphenyls (PCB) [4].
  • Domestic cat major allergen chain 1 (fel d I-A) and chain 2 (fel d I-B), which form a heterodimeric structure. Fel DI contains an additional disulfide bridge [5].
  • Human mammaglobin, a mammary-specific protein [6].
  • Rat prostatic steroid-binding protein C3 [7].

The profile we developed covers the four α-helices of the SCGB monomere.

Note:

This profile replaces two patterns whose specificity was inadequate.

Note:

The SCGB family was formerly known as the uteroglobin/Clara cell 10-kDa (UTG/CC10) family.

Last update:

April 2007 / Patterns removed, profile added and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

SCGB, PS51311; Secretoglobin (SCGB) family profile  (MATRIX)


References

1AuthorsKlug J. Beier H.M. Bernard A. Chilton B.S. Fleming T.P. Lehrer R.I. Miele L. Pattabiraman N. Singh G.
TitleUteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report.
SourceAnn. N. Y. Acad. Sci. 923:348-354(2000).
PubMed ID11193777

2AuthorsCallebaut I. Poupon A. Bally R. Demaret J.P. Housset D. Delettre J. Hossenlopp P. Mornon J.P.
TitleThe uteroglobin fold.
SourceAnn. N. Y. Acad. Sci. 923:90-112(2000).
PubMed ID11193783

3AuthorsBally R. Delettre J.
TitleStructure and refinement of the oxidized P21 form of uteroglobin at 1.64 A resolution.
SourceJ. Mol. Biol. 206:153-170(1989).
PubMed ID2704039

4AuthorsUmland T.C. Swaminathan S. Singh G. Warty V. Furey W. Pletcher J. Sax M.
TitleStructure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9 A resolution.
SourceNat. Struct. Biol. 1:538-545(1994).
PubMed ID7664082

5AuthorsKaiser L. Groenlund H. Sandalova T. Ljunggren H.-G. van Hage-Hamsten M. Achour A. Schneider G.
TitleThe crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family.
SourceJ. Biol. Chem. 278:37730-37735(2003).
PubMed ID12851385
DOI10.1074/jbc.M304740200

6AuthorsWatson M.A. Fleming T.P.
TitleMammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer.
SourceCancer Res. 56:860-865(1996).
PubMed ID8631025

7AuthorsParker M.G. White R. Hurst H. Needham M. Tilly R.
TitleProstatic steroid-binding protein. Isolation and characterization of C3 genes.
SourceJ. Biol. Chem. 258:12-15(1983).
PubMed ID6294095



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