PROSITE documentation PDOC00369
S-adenosylmethionine synthase signatures


S-adenosylmethionine synthase (EC is the enzyme that catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP [1]. AdoMet is an important methyl donor for transmethylation and is also the propylamino donor in polyamine biosynthesis.

In bacteria there is a single isoform of AdoMet synthase (gene metK), there are two in budding yeast (genes SAM1 and SAM2) and in mammals while in plants there is generally a multigene family.

The sequence of AdoMet synthase is highly conserved throughout isozymes and species. We selected two signature patterns for this type of enzyme; the first is a hexapeptide which seems to be involved in ATP-binding; the second is an almost perfectly conserved glycine-rich nonapeptide.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

ADOMET_SYNTHASE_1, PS00376; S-adenosylmethionine synthase signature 1  (PATTERN)

ADOMET_SYNTHASE_2, PS00377; S-adenosylmethionine synthase signature 2  (PATTERN)


1AuthorsHorikawa S. Sasuga J. Shimizu K. Ozasa H. Tsukada K.
TitleMolecular cloning and nucleotide sequence of cDNA encoding the rat kidney S-adenosylmethionine synthetase.
SourceJ. Biol. Chem. 265:13683-13686(1990).
PubMed ID1696256

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