PROSITE documentation PDOC00369S-adenosylmethionine synthase signatures
S-adenosylmethionine synthase (EC 2.5.1.6) is the enzyme that catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP [1]. AdoMet is an important methyl donor for transmethylation and is also the propylamino donor in polyamine biosynthesis.
In bacteria there is a single isoform of AdoMet synthase (gene metK), there are two in budding yeast (genes SAM1 and SAM2) and in mammals while in plants there is generally a multigene family.
The sequence of AdoMet synthase is highly conserved throughout isozymes and species. We selected two signature patterns for this type of enzyme; the first is a hexapeptide which seems to be involved in ATP-binding; the second is an almost perfectly conserved glycine-rich nonapeptide.
Last update:April 2006 / Pattern revised.
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| 1 | Authors | Horikawa S. Sasuga J. Shimizu K. Ozasa H. Tsukada K. |
| Title | Molecular cloning and nucleotide sequence of cDNA encoding the rat kidney S-adenosylmethionine synthetase. | |
| Source | J. Biol. Chem. 265:13683-13686(1990). | |
| PubMed ID | 1696256 |
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