PROSITE documentation PDOC00372
Profilin signature


Profilin [1,2] is a small eukaryotic protein that binds to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerization of actin into filaments (F-actin). It can also, in certain circumstance promotes actin polymerization. Profilin also binds to polyphosphoinositides such as PIP2.

Overall sequence similarity among profilin from organisms which belong to different phyla (ranging from fungi to mammals) is low, but the N-terminal region is relatively well conserved. That region is thought to be involved in the binding to actin. The signature pattern for profilin is based on conserved residues at the N-terminal extremity.

A protein structurally similar to profilin is present in the genome of variola and vaccinia viruses (gene A42R).

Last update:

November 1995 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PROFILIN, PS00414; Profilin signature  (PATTERN)


1AuthorsHaarer B.K. Brown S.S.
TitleStructure and function of profilin.
SourceCell Motil. Cytoskeleton 17:71-74(1990).
PubMed ID2257632

2AuthorsSohn R.H. Goldschmidt-Clermont P.J.
TitleProfilin: at the crossroads of signal transduction and the actin cytoskeleton.
SourceBioEssays 16:465-472(1994).
PubMed ID7945274

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