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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00414


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PURL: https://purl.expasy.org/prosite/signature/PS00414

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General information about the entry

Entry name [info] PROFILIN
Accession [info] PS00414
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-DEC-1991 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00372

Name and characterization of the entry

Description [info] Profilin signature.
Pattern [info] 
<x(0,1)-[STA]-x(0,1)-W-[DENQH]-x-[YI]-x-[DEQ].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 229 in 229 different sequences
Number of true positive hits 225 in 225 different sequences
Number of 'unknown' hits 0
Number of false positive hits 4 in 4 different sequences
Number of false negative sequences 16
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 98.25 %
Recall (true positives / (true positives + false negatives)) 93.36 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 225 sequences 

PRF01_KALTU (C6JWH0), PRF02_KALTU (E2D0Y9), PRF03_KALTU (W8P570), 

PRF1_ARATH  (Q42449), PRF2_ARATH  (Q42418), PRF3_ARATH  (Q9FE63), 
PRF4_ARATH  (Q38904), PRF5_ARATH  (Q38905), PRO10_MAIZE (A4KA59), 
PRO10_PHLPR (A4KA38), PRO11_MAIZE (A4KA60), PRO12_MAIZE (A4KA61), 
PRO1A_ACACA (P68696), PRO1B_ACACA (Q95VF7), PROAA_OLEEU (A4GD56), 
PROAB_OLEEU (P0DKE6), PROAC_OLEEU (P0DKE7), PROAD_OLEEU (P0DKE8), 
PROAE_OLEEU (P0DKE9), PROAF_OLEEU (P0DKF0), PROAG_OLEEU (P0DKF1), 
PROAH_OLEEU (P0DKF2), PROAI_OLEEU (P0DKF3), PROAJ_OLEEU (A4GD58), 
PROAK_OLEEU (A4GDQ6), PROAL_OLEEU (A4GDQ8), PROAM_OLEEU (P0DKF4), 
PROAN_OLEEU (P0DKF5), PROAO_OLEEU (P0DKF6), PROAP_OLEEU (P0DKF7), 
PROAQ_OLEEU (P0DKF8), PROAR_OLEEU (P0DKF9), PROAS_OLEEU (A4GDR1), 
PROAT_OLEEU (A4GDR3), PROAU_OLEEU (A4GDR4), PROAV_OLEEU (A4GDR6), 
PROAW_OLEEU (A4GDR7), PROAX_OLEEU (A4GDR8), PROAY_OLEEU (A4GDR9), 
PROAZ_OLEEU (A4GDS0), PROBA_OLEEU (A4GDS6), PROBB_OLEEU (A4GDS7), 
PROBC_OLEEU (A4GDS9), PROBD_OLEEU (A4GDT0), PROBE_OLEEU (A4GDT1), 
PROBF_OLEEU (A4GDT3), PROBH_OLEEU (A4GDT5), PROBI_OLEEU (A4GDT9), 
PROBJ_OLEEU (A4GDU0), PROBK_OLEEU (A4GDU2), PROBL_OLEEU (A4GDU3), 
PROBM_OLEEU (A4GDU5), PROBN_OLEEU (A4GDU6), PROBO_OLEEU (A4GE38), 
PROBP_OLEEU (A4GE39), PROBQ_OLEEU (A4GE42), PROBR_OLEEU (A4GE44), 
PROBS_OLEEU (A4GE45), PROBT_OLEEU (A4GE47), PROBU_OLEEU (A4GE48), 
PROBV_OLEEU (A4GE49), PROBW_OLEEU (A4GE50), PROBX_OLEEU (A4GE53), 
PROBY_OLEEU (A4GE54), PROBZ_OLEEU (A4GE55), PROCA_OLEEU (A4GFB7), 
PROCB_OLEEU (P0DKG0), PROCC_OLEEU (P0DKG1), PROCE_OLEEU (A4GFC0), 
PROCF_OLEEU (A4GFC2), PROCH_OLEEU (A4GFC4), PROCI_OLEEU (A4KA49), 
PROCJ_OLEEU (A4KA50), PROCK_OLEEU (A4KA51), PROCL_OLEEU (A4KA52), 
PROCM_OLEEU (A4KA53), PROCN_OLEEU (A4KA54), PROF1_AMBAR (Q64LH1), 
PROF1_ARTVU (Q8H2C9), PROF1_BETPN (P25816), PROF1_BOVIN (P02584), 
PROF1_CAEEL (Q9XW16), PROF1_CITSI (P84177), PROF1_CORAV (A4KA39), 
PROF1_DICDI (P26199), PROF1_ENTH1 (P49230), PROF1_HEVBR (O65812), 
PROF1_HORVU (P52184), PROF1_HUMAN (P07737), PROF1_LILLO (Q9SNW7), 
PROF1_MAIZE (P35081), PROF1_MALDO (Q9XF40), PROF1_MOUSE (P62962), 
PROF1_PARJU (Q9XG85), PROF1_PHAVU (P49231), PROF1_PHLPR (P35079), 
PROF1_PHYPO (P22271), PROF1_RAT   (P62963), PROF1_RICCO (O82572), 
PROF1_SOLLC (Q41344), PROF1_SOYBN (O65809), PROF1_STRPU (P32006), 
PROF1_TOBAC (P41372), PROF1_WHEAT (P49232), PROF2_ACACA (P19984), 
PROF2_AMBAR (Q64LH2), PROF2_ARTVU (Q8H2C8), PROF2_BETPN (A4K9Z8), 
PROF2_BOVIN (Q09430), PROF2_CORAV (A4KA40), PROF2_DICDI (P26200), 
PROF2_HEVBR (Q9STB6), PROF2_HUMAN (P35080), PROF2_LILLO (Q9SNW6), 
PROF2_MACFA (Q4R4P8), PROF2_MAIZE (P35082), PROF2_MALDO (Q9XF41), 
PROF2_MOUSE (Q9JJV2), PROF2_PARJU (Q9T0M8), PROF2_PHLPR (O24650), 
PROF2_PHYPO (P18322), PROF2_PONAB (Q5R4E2), PROF2_RAT   (Q9EPC6), 
PROF2_SOLLC (Q93YG7), PROF2_SOYBN (O65810), PROF2_TOBAC (Q9ST99), 
PROF2_WHEAT (P49233), PROF3_AMBAR (Q64LH0), PROF3_CORAV (A4KA44), 
PROF3_DICDI (Q8T8M2), PROF3_HEVBR (Q9M7N0), PROF3_LILLO (Q9SNW5), 
PROF3_MAIZE (P35083), PROF3_MALDO (Q9XF42), PROF3_PHLPR (O24282), 
PROF3_TOBAC (Q9ST98), PROF4_CORAV (A4KA45), PROF4_HEVBR (Q9M7M9), 
PROF4_MAIZE (O22655), PROF4_PHLPR (A4KA31), PROF5_CORAV (A4KA41), 
PROF5_HEVBR (Q9M7M8), PROF5_MAIZE (Q9FR39), PROF5_PHLPR (A4KA32), 
PROF6_CORAV (A4KA43), PROF6_HEVBR (Q9LEI8), PROF6_MAIZE (A4KA55), 
PROF6_PHLPR (A4KA33), PROF7_MAIZE (A4KA56), PROF7_PHLPR (A4KA34), 
PROF8_MAIZE (A4KA57), PROF8_PHLPR (A4KA36), PROF9_MAIZE (A4KA58), 
PROF9_PHLPR (A4KA37), PROFA_OLEEU (O24169), PROFA_ORYSJ (Q9FUD1), 
PROFB_OLEEU (O24170), PROFC_OLEEU (O24171), PROFD_OLEEU (P0DKD0), 
PROFF_OLEEU (A4GCR6), PROFG_OLEEU (P0DKD1), PROFH_OLEEU (P0DKD2), 
PROFI_OLEEU (P0DKD3), PROFJ_OLEEU (P0DKD4), PROFK_OLEEU (P0DKD5), 
PROFL_OLEEU (P0DKD6), PROFM_OLEEU (P0DKD7), PROFN_OLEEU (P0DKD8), 
PROFO_OLEEU (P0DKD9), PROFP_OLEEU (A4GCR7), PROFQ_OLEEU (A4GCR8), 
PROFR_OLEEU (P0DKE0), PROFS_OLEEU (P0DKE1), PROFU_OLEEU (P0DKE2), 
PROFV_OLEEU (P0DKE3), PROFW_OLEEU (P0DKE4), PROFX_OLEEU (P0DKE5), 
PROFX_ORYSI (P83647), PROFX_ORYSJ (Q5VMJ3), PROFY_OLEEU (A4GD54), 
PROFZ_OLEEU (A4GD55), PROF_ACTDE  (C0HL99), PROF_ANACO  (Q94JN2), 
PROF_APIGR  (Q9XF37), PROF_ARAHY  (Q9SQI9), PROF_BOMMO  (Q68HB4), 
PROF_BRABE  (Q8T938), PROF_BRANA  (Q9FUB8), PROF_CANAX  (P53696), 
PROF_CAPAN  (Q93YI9), PROF_CHEAL  (Q84V37), PROF_CITLA  (Q5XWE1), 
PROF_CLYJA  (P18321), PROF_CROSA  (Q5EF31), PROF_CUCME  (Q5FX67), 
PROF_CWPXB  (Q77DS0), PROF_CWPXG  (Q80DT4), PROF_CYNDA  (O04725), 
PROF_DAUCA  (Q8SAE6), PROF_DROME  (P25843), PROF_FRAAN  (P0C0Y3), 
PROF_HELAN  (O81982), PROF_HELCR  (P18320), PROF_LITCN  (Q941H7), 
PROF_MERAN  (O49894), PROF_MONPV  (A0A7H0DND9), PROF_MONPZ  (Q8V4T7), 
PROF_MUSAC  (Q94JN3), PROF_PHODC  (Q8L5D8), PROF_PRUAV  (Q9XF39), 
PROF_PRUDU  (Q8GSL5), PROF_PRUPE  (Q8GT39), PROF_PYRCO  (Q9XF38), 
PROF_RABPU  (Q6RZE1), PROF_SCHPO  (P39825), PROF_SUBDO  (Q9U0E6), 
PROF_TETPY  (P23412), PROF_TRYBB  (Q26734), PROF_VACCA  (O57243), 
PROF_VACCC  (P68695), PROF_VACCT  (Q77TH1), PROF_VACCW  (Q76ZN5), 
PROF_VAR67  (P0DSW5), PROF_VARV   (P0DSW6), PROF_YEAST  (P07274)
» more

UniProtKB/Swiss-Prot
False negative sequences		 16 sequences 

PROF2_CAEEL (Q20025), PROF3_BOVIN (Q32PB1), PROF3_CAEEL (Q21193), 

PROF3_HUMAN (P60673), PROF3_MOUSE (Q9DAD6), PROF3_RAT   (M0RCP6), 
PROF3_WHEAT (P49234), PROF4_BOVIN (Q2NKT1), PROF4_HUMAN (Q8NHR9), 
PROF4_MOUSE (Q9D6I3), PROF4_RAT   (Q5IRJ7), PROF_APIME  (Q6QEJ7), 
PROF_NAEPR  (Q6QNF8), PROF_PLABE  (B8QYR5), PROF_PLAF7  (Q8I2J4), 
PROF_PLAFX  (P86294)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

PROF_BETVU  (P85984)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			4 sequences
			


			
BIOF_PROMH  (B4ESU4), LCGA_LACLL  (P36961), PSB30_PSINU (Q8WI31), 

			
YECM_ECOLI  (P52007)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			46 PDB
			


			pdb_00001a0k; pdb_00001acf; pdb_00001cjf; pdb_00001cqa; pdb_00001d1j; pdb_00001f2k; pdb_00001fik; pdb_00001fil; pdb_00001g5u; pdb_00001hlu; pdb_00001k0k; pdb_00001pfl; 
			
				pdb_00001pne; pdb_00001prq; pdb_00001ypr; pdb_00002acg; pdb_00002btf; pdb_00002pav; pdb_00002pbd; pdb_00002prf; pdb_00002v8c; pdb_00002v8f; pdb_00003chw; pdb_00003d9y; 
				pdb_00003dav; pdb_00003nul; pdb_00003u4l; pdb_00003ub5; pdb_00004x1l; pdb_00004x1m; pdb_00004x25; pdb_00005fds; pdb_00005feg; pdb_00005nzb; pdb_00005nzc; pdb_00006iqf; 
				pdb_00006iqi; pdb_00006iqj; pdb_00006nas; pdb_00006nbe; pdb_00006nbw; pdb_00007kyw; pdb_00007p1h; pdb_00008bjj; pdb_00008rty; pdb_00009azp
			
			

			» more