|PROSITE documentation PDOC00374|
Avian leukemia virus E26 is a replication defective retrovirus that induces a mixed erythroid/myeloid leukemia in chickens. E26 virus carries two distinct oncogenes, v-myb and v-ets. The ets portion of this oncogene is required for the induction of erythroblastosis. V-ets and c-ets-1, its cellular progenitor, have been shown  to be nuclear DNA-binding proteins. Ets-1 differs slightly from v-ets at its carboxy-terminal region. In most species where it has been sequenced, c-ets-1 exists in various isoforms generated by alternative splicing and differential phosphorylation.
A number of proteins, that share regions of similarity with v-ets/c-ets-1, have been found and are listed below:
All these proteins contain a conserved domain, the 'ETS-domain', [2,3,4,5] involved in DNA-binding. It seems to recognize purine-rich sequences . This domain, of about 85 to 90 amino acids, is rich in aromatic and positively charged residues. It is generally localized at the C-terminus of the protein, with the exception of ELF-1, ELK-1, ELK-3, ELK-4 and ERF where it is found at the N-terminus.
We have derived two signature patterns for the ETS-domain. The first one is based on a highly conserved region in the N-terminal part of the domain, while the second is based on a region in the second third of the domain. The profile spans the complete domain.Last update:
April 2006 / Pattern revised.
PROSITE methods (with tools and information) covered by this documentation:
|1||Authors||Reddy E.S.P. Rao V.N.|
|Title||Localization and modulation of the DNA-binding activity of the human c-ets-1 protooncogene.|
|Source||Cancer Res. 50:5013-5016(1990).|
|2||Authors||Karim F.D. Urness L.D. Thummel C.S. Klemsz M.J. McKercher S.R. Celada A. Van Beveren C. Maki R.A. Gunther C.V. Nye J.A.|
|Title||The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence.|
|Source||Genes Dev. 4:1451-1453(1990).|
|3||Authors||McLeod K. Leprince D. Stehelin D.|
|Source||Trends Biochem. Sci. 17:251-256(1992).|
|4||Authors||Laudet V. Niel C. Duterque-Coquillaud M. Leprince D. Stehelin D.|
|Title||Evolution of the ets gene family.|
|Source||Biochem. Biophys. Res. Commun. 190:8-14(1993).|
|5||Authors||Wasylyk B. Hahn S.L. Giovane A.|
|Title||The Ets family of transcription factors.|
|Source||Eur. J. Biochem. 211:7-18(1993).|
|6||Authors||Wang C.-Y. Petryniak B. Ho I.-C. Thompson C.B. Leiden J.M.|
|Title||Evolutionarily conserved Ets family members display distinct DNA binding specificities.|
|Source||J. Exp. Med. 175:1391-1399(1992).|