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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE documentation PDOC00375
Bacterial quinoprotein dehydrogenases signatures


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PURL: https://purl.expasy.org/prosite/documentation/PDOC00375

Description

Pyrrolo-quinoline quinone (PQQ) is redox coenzyme, which serves as a cofactor for a number of enzymes (quinoproteins) and particularly for some bacterial dehydrogenases [1,2]. A number of these bacterial quinoproteins are clearly evolutionary related. These proteins are listed below.

  • Methanol dehydrogenases (MDH) (EC 1.1.99.8), from methylotrophs.
  • Ethanol dehydrogenases from Acetobacter aceti [3].
  • Glucose dehydrogenase (EC 1.1.5.2) from Acinetobacter calcoaceticus, Escherichia coli, and Gluconobacter oxydans [4].

These dehydrogenases all have from 600 to 800 amino acids. We developed two signature patterns for these proteins using sequence data from well conserved regions: the first one is located in the N-terminal half while the second one is from the C-terminal half.

Last update:

December 2004 / Patterns and text revised.

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Technical section

PROSITE methods (with tools and information) covered by this documentation:

BACTERIAL_PQQ_1, PS00363; Bacterial quinoprotein dehydrogenases signature 1  (PATTERN)

BACTERIAL_PQQ_2, PS00364; Bacterial quinoprotein dehydrogenases signature 2  (PATTERN)


References

1AuthorsDuine J.A. Jongejan J.A.
TitleQuinoproteins, enzymes with pyrrolo-quinoline quinone as cofactor.
SourceAnnu. Rev. Biochem. 58:403-426(1989).
PubMed ID2549854
DOI10.1146/annurev.bi.58.070189.002155

2AuthorsGallop P.M. Paz M.A. Flueckiger R. Kagan H.M.
TitlePQQ, the elusive coenzyme.
SourceTrends Biochem. Sci. 14:343-346(1989).
PubMed ID2572081

3AuthorsInoue T. Sunagawa M. Mori A. Imai C. Fukuda M. Takagi M. Yano K.
TitleCloning and sequencing of the gene encoding the 72-kilodalton dehydrogenase subunit of alcohol dehydrogenase from Acetobacter aceti.
SourceJ. Bacteriol. 171:3115-3122(1989).
PubMed ID2722742

4AuthorsCleton-Jansen A.-M. Dekker S. van de Putte P. Goosen N.
SourceMol. Gen. Genet. 229:206-212(1991).



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